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CS-W001157 4
Total: USD 88.00

2,4-Dihydroxy-6-methylnicotinonitrile

  • CAS No. 67643-17-8

  • Cat. No. CS-0011616
  • Purity≥98%
  • MDL No.MFCD11847535

*For research and further manufacturing use only, not for direct human use.

2,4-Dihydroxy-6-methylnicotinonitrile|CS-0011616

Structure of 67643-17-8

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General Information

  • CAS No. 67643-17-8
  • Cat. No. CS-0011616
  • Purity ≥98%
  • MDL No. MFCD11847535
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₆N₂O₂
  • Molecular Weight 150.13
  • Synonym(s) 4-Hydroxy-6-Methyl-2-oxo-1,2-dihydro-pyridine-3-carbonitrile
  • SMILES CC1=CC(O)=C(C#N)C(N1)=O

Description

2,4-Dihydroxy-6-methylnicotinonitrile features a pyridine core bearing strategically positioned hydroxyl and nitrile groups, enabling robust coordination in metal complexation. The methyl substituent enhances lipophilicity and metabolic stability. This compound serves as a key intermediate in the synthesis of bioactive heterocycles and functional materials.

Application

2,4-Dihydroxy-6-methylnicotinonitrile serves as a versatile building block in heterocyclic synthesis, enabling efficient access to substituted pyridine scaffolds. Its ortho-diol and nitrile functionalities support diverse transformations including cyclization, oxidation, and nucleophilic addition. The methyl group enhances metabolic stability and provides a handle for further functionalization, while the compound exhibits bench stability and compatibility with standard purification methods.

Safety Information

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GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301-H311-H331
Precautionary Statements : P264-P270-P330-P405-P501

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Computational Chemistry Data

  • TPSA   76.88
  • LogP   0.2606
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   0

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