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CS-W001157 4
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Methyl 3-amino-2-chloroisonicotinate

  • CAS No. 173435-41-1

  • Cat. No. CS-W003048
  • Purity≥98%
  • MDL No.MFCD03411723

*For research and further manufacturing use only, not for direct human use.

Methyl 3-amino-2-chloroisonicotinate|CS-W003048

Structure of 173435-41-1

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General Information

  • CAS No. 173435-41-1
  • Cat. No. CS-W003048
  • Purity ≥98%
  • MDL No. MFCD03411723
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₇ClN₂O₂
  • Molecular Weight 186.60
  • Synonym(s) methyl 3-amino-2-chloropyridine-4-carboxylate
  • SMILES O=C(OC)C1=CC=NC(Cl)=C1N

Description

Methyl 3-amino-2-chloroisonicotinate features a chlorinated pyridine core with complementary amine and ester functionalities, enabling direct incorporation into heterocyclic scaffolds. The para-amino group enhances nucleophilicity, while the ortho-chloro substituent facilitates palladium-catalyzed coupling reactions under standard conditions. This bench-stable reagent supports efficient synthesis of bioactive intermediates in medicinal chemistry workflows.

Application

Methyl 3-amino-2-chloroisonicotinate serves as a versatile building block in medicinal chemistry, enabling efficient access to bioactive heterocycles through standard coupling and cyclization protocols. The ortho-chloro group facilitates palladium-catalyzed cross-coupling reactions, while the amino and ester functionalities offer complementary sites for derivatization. Its bench-stable nature and compatibility with common protecting group strategies support streamlined synthesis of complex scaffolds relevant to pharmaceutical development.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   65.21
  • LogP   1.1038
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   1

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