2-(3-(Methoxymethyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Name: 2-(3-(Methoxymethyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
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CAS No. 675605-91-1
Cat. No. CS-0137307
Purity≥95%
MDL No.MFCD06795646

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2-(3-(Methoxymethyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane|CS-0137307

Structure of 675605-91-1

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General Information

CAS No. 675605-91-1
Cat. No. CS-0137307
Purity ≥95%
MDL No. MFCD06795646
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₄H₂₁BO₃
Molecular Weight 248.13
Synonym(s) 3-(METHOXYMETHYL)PHENYLBORONIC ACID, PINACOL ESTER
SMILES CC1(C)C(C)(C)OB(C2=CC=CC(COC)=C2)O1

Description

This boronate ester features a methoxymethyl-substituted phenyl moiety integrated into a stable tetramethyl-1,3,2-dioxaborolane scaffold. Designed for efficient Suzuki-Miyaura coupling, it delivers high functional group tolerance and reliable reactivity under standard conditions. The protected boron group ensures excellent shelf stability and moisture resistance during handling.

Application

2-(3-(Methoxymethyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane serves as a stable, bench-ready boronate building block for Suzuki-Miyaura cross-coupling reactions. The methoxymethyl group provides orthogonal protection and enhanced solubility, enabling efficient late-stage functionalization in complex molecule synthesis. Its high functional group tolerance and predictable reactivity facilitate reliable C–C bond formation under mild conditions.

Synthesis

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- In-stock
  
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- In-stock
  
  73183-34-3
- ~%
- In-stock
  
  675605-91-1
References
- NOVARTIS AG; NOVARTIS PHARMA GMBH Patent: WO2004/69256 A1, 2004 ; Location in patent: Page/Page column 114-115 ; WO 2004/069256 A1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H312-H332
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P501

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Computational Chemistry Data

TPSA 27.69
LogP 2.1322
H_Acceptors 3
H_Donors 0
Rotatable_Bonds 3

Other Classifications

Building Blocks Functional Group Boronic Acid And Its Ester

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

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2-(3-(Methoxymethyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

CAS No. 675605-91-1

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