2-Amino-4-methoxy-5-(3-morpholinopropoxy)benzonitrile

Name: 2-Amino-4-methoxy-5-(3-morpholinopropoxy)benzonitrile
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 675126-27-9
Cat. No. CS-0022482
Purity≥97%
MDL No.MFCD11110477

HazMat Fee +

HazMat Fee

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

The shipment is processed through FedEx Ground under the Limited Quantity option.

Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

2-Amino-4-methoxy-5-(3-morpholinopropoxy)benzonitrile|CS-0022482

Structure of 675126-27-9

Size

Price

Quantity

* Please select Quantity before adding items.

General Information

CAS No. 675126-27-9
Cat. No. CS-0022482
Purity ≥97%
MDL No. MFCD11110477
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₅H₂₁N₃O₃
Molecular Weight 291.35
Synonym(s) Benzonitrile, 2-amino-4-methoxy-5-[3-(4-morpholinyl)propoxy]-
SMILES N#CC1=CC(OCCCN2CCOCC2)=C(OC)C=C1N

Description

This boronate moiety integrates a methoxy-substituted aromatic core with a morpholinopropoxy side chain, delivering enhanced solubility and metabolic stability. The para-nitro group enables efficient coupling in Suzuki-Miyaura reactions, while the amino functionality offers direct derivatization potential for probe development.

Application

2-Amino-4-methoxy-5-(3-morpholinopropoxy)benzonitrile serves as a versatile building block for heterocyclic synthesis, enabling efficient access to substituted benzimidazoles and quinoline scaffolds. The ortho-amino and nitrile groups facilitate cyclization under mild conditions, while the methoxy and morpholinopropoxy substituents provide solubility and modulate electronic properties. Bench-stable and compatible with standard purification protocols, it functions effectively in multi-step medicinal chemistry campaigns requiring functional group tolerance and predictable reactivity.

Synthesis

Route1
- In-stock
  
  675126-26-8
- ~10%
- In-stock
  
  675126-27-9
References
- ASTRAZENECA AB; ASTRAZENECA UK LIMITED Patent: WO2004/24703 A1, 2004 ; Location in patent: Page 10 ; WO 2004/024703 A1
Route2
- 7357-67-7
- ~%
- In-stock
  
  675126-27-9
References
- Bioorganic and Medicinal Chemistry Letters, , vol. 16, # 15 p. 4102 - 4106
Route3
- 675126-28-0
- ~%
- In-stock
  
  675126-27-9
References
- Bioorganic and Medicinal Chemistry Letters, , vol. 16, # 15 p. 4102 - 4106

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302
Precautionary Statements : P264-P270-P330-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

TPSA 80.74
LogP 1.25018
H_Acceptors 6
H_Donors 1
Rotatable_Bonds 6

Other Classifications

Building Blocks Functional Group Cyanide/Nitrile

Building Blocks Skeleton Aliphatic heterocycle compounds Morpholine compounds

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

675126-27-9 sigma675126-27-9 manufacturer675126-27-9 price675126-27-9 structure675126-27-9 SDSbuy 675126-27-9675126-27-9 supplier675126-27-9 uses675126-27-9 molecular weightprice of 675126-27-9675126-27-9 chemical name formula of 675126-27-9

Salutation:	*Country or Region:
*Applicant Name:	*Organization Name:
*Email Address:	Quantity:
CAS NO. :	Product Name:
Remarks:
Upload Pictures

CAS.No.		Product Name
Applicant Name *		Email Address *
Phone Number *		Organization Name*
Country or Region*		Quantity*
Remarks:

Product Name:
Cat. No.: .		CAS NO. :
Quantity:

2-Amino-4-methoxy-5-(3-morpholinopropoxy)benzonitrile

CAS No. 675126-27-9

Recommended Products

General Information

Description

Application

Synthesis

References

References

References

Safety Information

Quality Control

Computational Chemistry Data

Similar Products

Other Classifications

Recently Viewed Products

Key Words