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CS-W001157 4
Total: USD 88.00

2-Bromobenzene-1,3-diol

  • CAS No. 6751-75-3

  • Cat. No. CS-W015980
  • Purity≥98%
  • MDL No.MFCD07779241

*For research and further manufacturing use only, not for direct human use.

2-Bromobenzene-1,3-diol|CS-W015980

Structure of 6751-75-3

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General Information

  • CAS No. 6751-75-3
  • Cat. No. CS-W015980
  • Purity ≥98%
  • MDL No. MFCD07779241
  • Storage RT, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₅BrO₂
  • Molecular Weight 189.01
  • Synonym(s) 2-Bromoresorcinol
  • SMILES OC1=CC=CC(O)=C1Br

Description

2-Bromobenzene-1,3-diol features a bromine-substituted aromatic ring bearing two ortho-hydroxyl groups, offering enhanced reactivity in electrophilic substitution and serving as a key intermediate in the synthesis of functionalized phenolic compounds.

Application

2-Bromobenzene-1,3-diol serves as a versatile ortho-diols building block for the synthesis of functionalized heterocycles and bioactive scaffolds. Its bromine substituent enables palladium-catalyzed coupling reactions, while the adjacent hydroxyl groups facilitate protection, oxidation, or cyclization processes. The compound exhibits good bench stability and is compatible with standard purification techniques, making it well-suited for iterative synthetic sequences in medicinal chemistry and process development.

Synthesis

  • Route1

    References

    • Kiehlmann, E.; Lauener, R. W. Canadian Journal of Chemistry, 1989 , vol. 67, p. 335 - 344
  • Route2
    • null|null
      108-46-3
    • ~93%
    • In-stock
      2-Bromobenzene-1,3-diol|CS-W015980
      6751-75-3

    References

    • Weimar, Marko; Duerner, Gerd; Bats, Jan W.; Goebel, Michael W. Journal of Organic Chemistry, 2010 , vol. 75, # 8 p. 2718 - 2721
  • Route3
    • null|null
      116595-48-3
    • ~%
    • In-stock
      2-Bromobenzene-1,3-diol|CS-W015980
      6751-75-3

    References

    • Journal of the American Chemical Society, , vol. 48, p. 3127

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302+H312+H332-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   40.46
  • LogP   1.8603
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   0

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