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CS-W001157 4
Total: USD 88.00

2,6-Dichloroquinazoline

  • CAS No. 67092-18-6

  • Cat. No. CS-0052131
  • Molecule weight199.04
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2,6-Dichloroquinazoline|CS-0052131

Structure of 67092-18-6

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General Information

  • CAS No. 67092-18-6
  • Cat. No. CS-0052131
  • Purity ≥97%
  • MDL No. None
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₄Cl₂N₂
  • Molecular Weight 199.04
  • Synonym(s) 2,6-dichloro-quinazoline
  • SMILES ClC1=CC2=CN=C(Cl)N=C2C=C1

Synthesis

  • Route1
    • 6-Chloroquinazolin-2-amine|CS-0135296
      20028-71-1
    • ~20%
    • 2,6-Dichloroquinazoline|CS-0052131
      67092-18-6

    References

    • AMGEN INC.; ALLEN, Jennifer R.; CHEN, Jian J.; FROHN, Michael J.; HU, Essa; LIU, Qingyian; PICKRELL, Alexander J.; RUMFELT, Shannon; RZASA, Robert M.; ZHONG, Wenge Patent: WO2011/143365 A1, 2011 ; Location in patent: Page/Page column 185 ; WO 2011/143365 A1
  • Route2
    • 6-Chloroquinazolin-2(1H)-one|CS-0488359
      60610-12-0
    • ~%
    • 2,6-Dichloroquinazoline|CS-0052131
      67092-18-6

    References

    • IMPERIAL CHEMICAL INDUSTRIES PLC Patent: EP248554 A2, 1987 ;
  • Route3

    References

    • Verheij, Mark H. P.; Thompson, Andrew J.; Van Muijlwijk-Koezen, Jacqueline E.; Lummis, Sarah C. R.; Leurs, Rob; De Esch, Iwan J. P. Journal of Medicinal Chemistry, 2012 , vol. 55, # 20 p. 8603 - 8614

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   25.78
  • LogP   2.9366
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   0

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