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CS-W001157 4
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1H-Pyrrolo[2,3-c]pyridine-3-carboxylic acid

  • CAS No. 67058-74-6

  • Cat. No. CS-0044734
  • Purity≥95%
  • MDL No.MFCD11845479

*For research and further manufacturing use only, not for direct human use.

1H-Pyrrolo[2,3-c]pyridine-3-carboxylic acid|CS-0044734

Structure of 67058-74-6

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General Information

  • CAS No. 67058-74-6
  • Cat. No. CS-0044734
  • Purity ≥95%
  • MDL No. MFCD11845479
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₆N₂O₂
  • Molecular Weight 162.15
  • Synonym(s) None
  • SMILES O=C(C1=CNC2=C1C=CN=C2)O

Description

1H-Pyrrolo[2,3-c]pyridine-3-carboxylic acid features a fused heterocyclic core with a carboxylic acid at the 3-position, enabling direct conjugation in medicinal chemistry scaffolds. The electron-deficient pyrrolopyridine framework supports robust coupling reactions and enhances metabolic stability in bioactive molecules. This bench-stable reagent integrates efficiently into diverse synthetic pathways requiring rigid, planar aromatic systems.

Application

1H-Pyrrolo[2,3-c]pyridine-3-carboxylic acid serves as a versatile heterocyclic building block in medicinal chemistry, enabling the construction of bioactive scaffolds through standard coupling and functionalization reactions. Its carboxylic acid functionality facilitates direct amide formation, esterification, and metal-mediated transformations, while the fused polycyclic core exhibits favorable bench stability and compatibility with diverse reaction conditions. This compound functions as a key structural motif in the synthesis of kinase inhibitors and other targeted therapeutics.

Synthesis

  • Route1
    • null|null
      1313266-67-9
    • ~84%
    • In-stock
      1H-Pyrrolo[2,3-c]pyridine-3-carboxylic acid|CS-0044734
      67058-74-6

    References

    • SANOFI; CHOI-SLEDESKI, Yong Mi; NIEDUZAK, Thaddeus R.; POLI, Gregory B.; SHUM, Patrick Wai-Kwok; STOKLOSA, Gregory T.; ZHAO, Zhicheng Patent: WO2011/78984 A1, 2011 ; Location in patent: Page/Page column 34 ; WO 2011/078984 A1
  • Route2

    References

    • WO2011/78984 A1, ; WO 2011/078984 A1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   65.98
  • LogP   1.2611
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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