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CS-W001157 4
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Pyrazin-2-ylmethanol

  • CAS No. 6705-33-5

  • Cat. No. CS-W018634
  • Purity≥96%
  • MDL No.MFCD01693938

*For research and further manufacturing use only, not for direct human use.

Pyrazin-2-ylmethanol|CS-W018634

Structure of 6705-33-5

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General Information

  • CAS No. 6705-33-5
  • Cat. No. CS-W018634
  • Purity ≥96%
  • MDL No. MFCD01693938
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₆N₂O
  • Molecular Weight None
  • Synonym(s) 2-(Hydroxymethyl)pyrazine
  • SMILES C1=NC=C(N=C1)CO

Description

Pyrazin-2-ylmethanol features a pyrazine ring bearing a primary alcohol group, offering a versatile scaffold for functionalization. This bench-stable, moisture-tolerant compound integrates readily into synthetic sequences requiring electron-deficient heteroaromatic handles. Its polar hydroxymethyl moiety enables direct coupling or derivatization in medicinal chemistry and materials science applications.

Application

Pyrazin-2-ylmethanol serves as a versatile building block in medicinal chemistry, enabling efficient access to pyrazine-containing scaffolds via oxidation, coupling, or functionalization reactions. Its benzylic alcohol functionality offers reliable reactivity in standard transformations, including Mitsunobu reactions and esterifications, while maintaining bench stability and compatibility with diverse functional groups. This compound facilitates the construction of complex heterocyclic systems relevant to API development.

Synthesis

  • Route1

    References

    • ASTRAZENECA AB; ASTRAZENECA UK LIMITED Patent: WO2004/93880 A1, 2004 ; Location in patent: Page/Page column 86 ; WO 2004/093880 A1
  • Route2
    • null|null
      19847-10-0
    • ~%
    • In-stock
      Pyrazin-2-ylmethanol|CS-W018634
      6705-33-5

    References

    • EP150984 B1, ;
  • Route3
    • null|null
      1025351-04-5
    • ~98%
    • In-stock
      Pyrazin-2-ylmethanol|CS-W018634
      6705-33-5

    References

    • Hasnik, Zbynek; Silhar, Peter; Hocek, Michal Synlett, 2008 , # 4 p. 543 - 546

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P305+P351+P338-P332+P313-P337+P313-P362+P364

Quality Control

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Computational Chemistry Data

  • TPSA   46.01
  • LogP   -0.0311
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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