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CS-W001157 4
Total: USD 88.00

4-Morpholinopicolinic acid

  • CAS No. 66933-68-4

  • Cat. No. CS-0155587
  • Purity≥98%
  • MDL No.MFCD06382849

*For research and further manufacturing use only, not for direct human use.

4-Morpholinopicolinic acid|CS-0155587

Structure of 66933-68-4

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General Information

  • CAS No. 66933-68-4
  • Cat. No. CS-0155587
  • Purity ≥98%
  • MDL No. MFCD06382849
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₂N₂O₃
  • Molecular Weight 208.21
  • Synonym(s) 4-(4-Morpholinyl)-picolinic acid
  • SMILES C1=CN=C(C=C1N2CCOCC2)C(=O)O

Description

4-Morpholinopicolinic acid features a morpholine ring fused to a picolinic acid scaffold, delivering enhanced solubility and metabolic stability. This structural combination enables efficient incorporation into bioactive molecules, particularly in medicinal chemistry campaigns targeting kinase inhibition and GPCR modulation. The molecule's balanced polarity supports robust conjugation under standard coupling conditions.

Application

4-Morpholinopicolinic acid serves as a versatile building block in medicinal chemistry, enabling the synthesis of bioactive heterocycles and pharmaceutical scaffolds. Its pyridine core supports diverse functionalization, while the morpholino group enhances solubility and modulates pharmacokinetic properties. The carboxylic acid functionality facilitates coupling reactions and salt formation, offering excellent bench stability and ease of purification in standard synthetic workflows.

Synthesis

  • Route1
    • Methyl 4-morpholinopicolinate|CS-1061901
      83728-67-0
    • ~%
    • In-stock
      4-Morpholinopicolinic acid|CS-0155587
      66933-68-4

    References

    • WO2012/3544 A1, ; Page/Page column 80 ; WO 2012/003544 A1
  • Route2

    References

    • WO2012/3544 A1, ; WO 2012/003544 A1
  • Route3
    • null|null
      82776-75-8
    • ~%
    • In-stock
      4-Morpholinopicolinic acid|CS-0155587
      66933-68-4
    • N-Cyclopentylbenzamide|CS-0259876
      53226-42-9

    References

    • Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, , vol. 36, # 6 p. 381 - 388

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   62.66
  • LogP   0.6164
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   2

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