2-Ethynylpyridin-4-amine

Name: 2-Ethynylpyridin-4-amine
Brand: ChemScene
Availability: InStock
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CAS No. 667932-24-3
Cat. No. CS-0186637
Purity≥95%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

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*For research and further manufacturing use only, not for direct human use.

Structure of 667932-24-3

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Description

2-Ethynylpyridin-4-amine features a terminal alkyne group conjugated to a pyridine ring bearing a primary amine, enabling efficient copper-catalyzed coupling reactions. This bifunctional scaffold integrates readily into complex molecular architectures via click chemistry, offering high reactivity and stability under standard conditions.

Application

2-Ethynylpyridin-4-amine serves as a versatile building block in transition-metal-catalyzed coupling reactions, enabling efficient access to conjugated heteroaryl systems. Its terminal alkyne and pyridyl amine functionalities support orthogonal reactivity, facilitating Sonogashira couplings and further functionalization. The compound exhibits good bench stability and ease of purification, making it suitable for scalable synthesis of advanced intermediates in medicinal chemistry and materials science applications.

General Information

CAS No. 667932-24-3
Cat. No. CS-0186637
Purity ≥95%
MDL No. None
Storage 4°C, protect from light, stored under nitrogen
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₇H₆N₂
Molecular Weight 118.14
Synonym(s) 4-Pyridinamine,2-ethynyl-(9CI)
SMILES C#CC1=NC=CC(=C1)N

Computational Chemistry Data

TPSA 38.91
LogP 0.6451
H_Acceptors 2
H_Donors 1
Rotatable_Bonds 0

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Other Classifications

Building Blocks Functional Group Alkyne

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Life Science Click Chemistry Reagents Alkyne

Chemical Biology Pharmaceutical Development and Drug Discovery Research Conjugation Chemistry/Click Chemistry Terminal Alkynes

Chemical Biology Conjugation Chemistry/Click Chemistry Terminal Alkynes

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2-Ethynylpyridin-4-amine

CAS No. 667932-24-3

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