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CS-W001157 4
Total: USD 88.00

4-Amino-2-methylpyridine

  • CAS No. 18437-58-6

  • Cat. No. CS-D0974
  • Purity≥95%
  • MDL No.MFCD00186509

*For research and further manufacturing use only, not for direct human use.

4-Amino-2-methylpyridine|CS-D0974

Structure of 18437-58-6

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General Information

  • CAS No. 18437-58-6
  • Cat. No. CS-D0974
  • Purity ≥95%
  • MDL No. MFCD00186509
  • Storage RT, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₈N₂
  • Molecular Weight None
  • Synonym(s) AKOS BBS-00006740
  • SMILES NC1=CC(C)=NC=C1

Description

4-Amino-2-methylpyridine features a pyridine core bearing an electron-rich amino group at the 4-position and a methyl substituent at the 2-position, enabling versatile integration into heterocyclic scaffolds. This bench-stable compound serves as a key building block for pharmaceutical intermediates and ligand design, where its dual functionality supports efficient coupling reactions and metal coordination.

Application

4-Amino-2-methylpyridine serves as a versatile building block in medicinal chemistry, enabling efficient construction of heterocyclic scaffolds through electrophilic substitution and transition-metal-catalyzed coupling reactions. Its ortho-directed reactivity and bench-stable nature facilitate straightforward functionalization and purification, making it well-suited for API development and process-scale synthesis.

Synthesis

  • Route1
    • null|null
      5470-66-6
    • ~99%
    • In-stock
      4-Amino-2-methylpyridine|CS-D0974
      18437-58-6

    References

    • WO2004/14913 A2, ; Page 81 ; WO 2004/014913 A2
  • Route2
    • 2-Methylpyridine-4-carboxamide|CS-0309339
      19354-04-2
    • ~%
    • In-stock
      4-Amino-2-methylpyridine|CS-D0974
      18437-58-6

    References

    • Roczniki Chemii, , vol. 31, p. 1147,1151 Chem.Abstr., , p. 10072
  • Route3
    • null|null
      5470-66-6
    • ~89%
    • In-stock
      4-Amino-2-methylpyridine|CS-D0974
      18437-58-6
    • In-stock
      4-Methoxy-2-methylpyridine|CS-W005919
      24103-75-1
    • null|null
      14045-17-1
    • null|null
      100421-65-6

    References

    • J. Appl. Chem. USSR (Engl. Transl.), , vol. 62, # 7.2 p. 1577 - 1586,1460 - 1468

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05,GHS07
Signal Word : Danger
UN#: 1759
Class : 8
Packing Group : Ⅲ
Hazard Statements : H302-H315-H318-H335
Precautionary Statements : P260-P264-P270-P271-P280-P301+P310-P302+P352-P304+P340-P305+P351+P338-P310-P312-P330-P332+P313-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   38.91
  • LogP   0.97222
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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