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CS-W001157 4
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1-Methyl-1H-imidazol-5-amine

  • CAS No. 66787-75-5

  • Cat. No. CS-0019280
  • Purity≥97%
  • MDL No.MFCD10001505

*For research and further manufacturing use only, not for direct human use.

1-Methyl-1H-imidazol-5-amine|CS-0019280

Structure of 66787-75-5

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General Information

  • CAS No. 66787-75-5
  • Cat. No. CS-0019280
  • Purity ≥97%
  • MDL No. MFCD10001505
  • Storage -20°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₇N₃
  • Molecular Weight 97.12
  • Synonym(s) N1-Methyl-5-aMinoiMidazole
  • SMILES NC1=CN=CN1C

Description

1-Methyl-1H-imidazol-5-amine features a methylated imidazole core with a primary amine at the 5-position, delivering enhanced solubility and nucleophilicity. This configuration enables direct incorporation into heterocyclic scaffolds and facilitates efficient coupling reactions under mild conditions. The compound serves as a key building block in medicinal chemistry and catalyst design.

Application

1-Methyl-1H-imidazol-5-amine serves as a versatile building block in medicinal chemistry, enabling efficient access to bioactive heterocycles. Its well-defined nucleophilicity at the 5-position facilitates direct functionalization and transition-metal-catalyzed coupling reactions. The molecule exhibits excellent bench stability, ease of purification, and compatibility with common protecting group strategies, making it ideal for modular synthesis of imidazole-based scaffolds in drug discovery campaigns.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   43.84
  • LogP   0.0023
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   0

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