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CS-W001157 4
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(R)-(-)-5-(Hydroxymethyl)-2-pyrrolidinone

  • CAS No. 66673-40-3

  • Cat. No. CS-W001840
  • Purity≥96%
  • MDL No.MFCD00077791

*For research and further manufacturing use only, not for direct human use.

(R)-(-)-5-(Hydroxymethyl)-2-pyrrolidinone|CS-W001840

Structure of 66673-40-3

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General Information

  • CAS No. 66673-40-3
  • Cat. No. CS-W001840
  • Purity ≥96%
  • MDL No. MFCD00077791
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₉NO₂
  • Molecular Weight 115.13
  • Synonym(s) D-Pyroglutaminol; (R)-(-)-5-(Hydroxymethyl)-2-pyrrolidinone
  • SMILES OC[C@H]1CCC(=O)N1

Description

(R)-(-)-5-(Hydroxymethyl)-2-pyrrolidinone features a chiral pyrrolidinone core with a pendant hydroxymethyl group, offering enhanced solubility and reactivity in asymmetric synthesis. This bench-stable, moisture-tolerant building block integrates readily into complex molecular architectures, enabling efficient access to bioactive heterocycles and pharmaceutical intermediates.

Synthesis

  • Route1

    References

    • CAYMAN CHEMICAL COMPANY, INC.; MYOMETRICS, LLC; BARRETT, Stephen, Douglas; CISKE, Fred, Lawrence; COLOMBO, Joseph, Michael; ENDRES, Gregory, William; GERMAIN, Bradlee, David; KORNILOV, Andriy; KRAMER, James, Bernard; UZIEBLO, Adam; OWEN, Thomas, Allen; O'MALLEY, James, Paul Patent: WO2014/15246 A1, 2014 ; Location in patent: Paragraph 0447-0448 ;
  • Route2

    References

    • Amstutz; Ringdahl; Karlen; Roch; Jenden Journal of Medicinal Chemistry, 1985 , vol. 28, # 12 p. 1760 - 1765
  • Route3

    References

    • Tetrahedron, , vol. 47, # 40 p. 8635 - 8652

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   49.33
  • LogP   -0.7427
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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