4-Aminomethyltetrahydropyran-4-ol hydrochloride

Name: 4-Aminomethyltetrahydropyran-4-ol hydrochloride
Brand: ChemScene
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CAS No. 666261-01-4
Cat. No. CS-0028292
Purity≥97%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
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4-Aminomethyltetrahydropyran-4-ol hydrochloride|CS-0028292

Structure of 666261-01-4

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General Information

CAS No. 666261-01-4
Cat. No. CS-0028292
Purity ≥97%
MDL No. None
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₁₄ClNO₂
Molecular Weight 167.63
Synonym(s) 4-(Aminomethyl)tetrahydro-2H-pyran-4-ol hydrochloride
SMILES [H]Cl.OC1(CN)CCOCC1

Description

4-Aminomethyltetrahydropyran-4-ol hydrochloride features a rigid tetrahydropyran core with a pendant primary amine and hydroxyl group, offering dual functionality for conjugation and solubility enhancement. This bench-stable salt integrates readily into peptide and small-molecule scaffolds, enabling efficient access to polar, bioactive architectures under standard conditions.

Application

4-Aminomethyltetrahydropyran-4-ol hydrochloride serves as a versatile bifunctional building block, combining a primary amine and a secondary alcohol within a stable tetrahydropyran ring. The hydrochloride salt enhances solubility and handling, enabling efficient derivatization in peptide coupling, urea formation, and reductive amination reactions. Its bench-stable nature and compatibility with standard protecting group strategies make it well-suited for medicinal chemistry campaigns involving cyclic ether scaffolds.

Synthesis

Route1
- 112799-02-7
- ~%
- In-stock
  
  666261-01-4
References
- US2006/94750 A1, ; Page/Page column 34 ; US 20060094750 A1
Route2
- 50289-10-6
- ~%
- In-stock
  
  666261-01-4
References
- US2009/76062 A1, ; Page/Page column 22-23 ; US 20090076062 A1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

TPSA 55.48
LogP -0.0916
H_Acceptors 3
H_Donors 2
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Alcohol

Building Blocks Skeleton Aliphatic heterocycle compounds Tetrahydropyran compounds

Key Words

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4-Aminomethyltetrahydropyran-4-ol hydrochloride

CAS No. 666261-01-4

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