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CS-W001157 4
Total: USD 88.00

rel-(3R,4S)-4-Aminotetrahydrofuran-3-ol

  • CAS No. 330975-13-8

  • Cat. No. CS-0047593
  • Purity≥97%
  • MDL No.MFCD18833631

*For research and further manufacturing use only, not for direct human use.

rel-(3R,4S)-4-Aminotetrahydrofuran-3-ol|CS-0047593

Structure of 330975-13-8

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General Information

  • CAS No. 330975-13-8
  • Cat. No. CS-0047593
  • Purity ≥97%
  • MDL No. MFCD18833631
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₉NO₂S
  • Molecular Weight 103.12
  • Synonym(s) 3-Furanol,4-aminotetrahydro-,(3R,4S)-rel-(9CI)
  • SMILES O[C@H]1COC[C@@H]1N

Description

rel-(3R,4S)-4-Aminotetrahydrofuran-3-ol is a stereochemically defined heterocyclic amino alcohol featuring a constrained tetrahydrofuran ring with adjacent amine and hydroxyl functionalities. This configuration enables precise integration into bioactive scaffolds, particularly in medicinal chemistry applications where chiral control and hydrogen-bonding capacity are critical. The molecule exhibits enhanced solubility and stability under standard handling conditions, facilitating use in peptide conjugation and macrocyclic synthesis workflows.

Application

rel-(3R,4S)-4-Aminotetrahydrofuran-3-ol serves as a stereochemically defined building block for the synthesis of bioactive heterocycles and peptide mimetics. Its functional group pattern—bearing both hydroxyl and primary amine moieties in a constrained tetrahydrofuran ring—enables efficient derivatization via acylation, alkylation, or coupling reactions. The compound exhibits good bench stability and facilitates regioselective transformations, supporting its use in medicinal chemistry campaigns requiring chiral, polar scaffolds with predictable reactivity.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   55.48
  • LogP   -1.2952
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   0

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