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CS-W001157 4
Total: USD 88.00

1,4-Dioxaspiro[4.5]decane-8-carboxylic acid

  • CAS No. 66500-55-8

  • Cat. No. CS-0037302
  • Purity≥97%
  • MDL No.MFCD11847571

*For research and further manufacturing use only, not for direct human use.

1,4-Dioxaspiro[4.5]decane-8-carboxylic acid|CS-0037302

Structure of 66500-55-8

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General Information

  • CAS No. 66500-55-8
  • Cat. No. CS-0037302
  • Purity ≥97%
  • MDL No. MFCD11847571
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₄O₄
  • Molecular Weight 186.21
  • Synonym(s) None
  • SMILES C1CC2(CCC1C(=O)O)OCCO2

Description

1,4-Dioxaspiro[4.5]decane-8-carboxylic acid is a rigid, spirocyclic diether with a pendant carboxylic acid group. This structural motif combines enhanced stereochemical stability with a polar functional handle, enabling its use in constrained molecular scaffolds for medicinal chemistry and macrocyclic synthesis.

Application

1,4-Dioxaspiro[4.5]decane-8-carboxylic acid serves as a rigid, bicyclic scaffold for medicinal chemistry and synthetic intermediates. Its spirocyclic architecture provides conformational constraint, while the carboxylic acid functionality enables direct derivatization or incorporation into bioactive molecules via standard coupling reactions. The molecule exhibits good bench stability and functional group tolerance, facilitating use in multi-step syntheses and heterocycle construction.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   55.76
  • LogP   1.0043
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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