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CS-W001157 4
Total: USD 88.00

Ethyl 1,4-dioxaspiro[4.5]decane-8-carboxylate

  • CAS No. 1489-97-0

  • Cat. No. CS-W005328
  • Purity≥95%
  • MDL No.MFCD00205582

*For research and further manufacturing use only, not for direct human use.

Ethyl 1,4-dioxaspiro[4.5]decane-8-carboxylate|CS-W005328

Structure of 1489-97-0

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General Information

  • CAS No. 1489-97-0
  • Cat. No. CS-W005328
  • Purity ≥95%
  • MDL No. MFCD00205582
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₁₈O₄
  • Molecular Weight 214.26
  • Synonym(s) LY-222211
  • SMILES O=C(C(CC1)CCC21OCCO2)OCC

Description

Ethyl 1,4-dioxaspiro[4.5]decane-8-carboxylate features a rigid spirocyclic architecture that imparts exceptional stereochemical stability. This scaffold integrates a masked aldehyde equivalent with a pendant ester group, enabling selective transformations in complex molecule synthesis. The bicyclic core resists ring-opening under standard conditions, offering reliable access to functionalized intermediates for medicinal chemistry and natural product derivatization.

Application

Ethyl 1,4-dioxaspiro[4.5]decane-8-carboxylate serves as a versatile bicyclic building block for the synthesis of complex heterocyclic scaffolds and bioactive molecules. Its spirocyclic core provides rigidity and defined stereochemistry, while the ester functionality enables straightforward derivatization via hydrolysis, reduction, or coupling reactions. The molecule exhibits excellent bench stability and facilitates efficient purification, making it well-suited for iterative synthetic sequences in medicinal chemistry and process development.

Synthesis

  • Route1

    References

    • Gruenenthal GmbH Patent: US2008/312231 A1, 2008 ; Location in patent: Page/Page column 17 ; US 20080312231 A1
  • Route2

    References

    • Stella Pharma Corporation; Osaka Prefecture University Public Corporation; KIRIHATA,Mitsunori; HATTORI,Yoshihide; UEHARA,Kohki; TAKENAKA,Hiroshi Patent: EP2602261 A1, 2013 ; Location in patent: Paragraph 0090; 0091 ;
  • Route3

    References

    • US3948939 A1, ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   44.76
  • LogP   1.4828
  • H_Acceptors   4
  • H_Donors   0
  • Rotatable_Bonds   2

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