Lot numbers can be found on the outside label of a product:
4-Chlorobenzo[b]thiophene
-
CAS No. 66490-33-3
- Cat. No. CS-0097337
- Purity≥97%
- MDL No.MFCD18451627
*For research and further manufacturing use only, not for direct human use.
![4-Chlorobenzo[b]thiophene|CS-0097337](https://file.chemscene.com/productPIC/CS-0097337.gif)
Structure of 66490-33-3
Please choose your location and provide accurate information for you
| Size |
|
Price | Quantity | |||
|---|---|---|---|---|---|---|
|
* Please select Quantity before adding items. |
||||||
Recommended Products
General Information
- CAS No. 66490-33-3
- Cat. No. CS-0097337
- Purity ≥97%
- MDL No. MFCD18451627
- Storage 4°C, stored under nitrogen
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₈H₅ClS
- Molecular Weight 168.64
- Synonym(s) 4-Chlorobenzothiophene
- SMILES ClC1=C(C=CS2)C2=CC=C1
Description
4-Chlorobenzo[b]thiophene features a fused benzothiophene core with a chloro substituent at the 4-position, delivering enhanced electron-withdrawal and improved metabolic stability. This structural motif integrates readily into pharmaceutical scaffolds and advanced materials, offering robust performance under standard synthetic conditions.
Application
4-Chlorobenzo[b]thiophene serves as a versatile heterocyclic building block in medicinal chemistry and materials science, enabling efficient transition-metal-catalyzed cross-coupling reactions. Its chlorine substituent facilitates Pd- or Ni-mediated functionalization, while the fused thiophene core provides robust stability and favorable electronic properties for downstream scaffold elaboration. The compound exhibits excellent bench stability and compatibility with standard purification protocols, making it ideal for iterative synthesis workflows.
Synthesis
-
Route1
-
In-stock
![4-Chlorobenzo[b]thiophene-2-carboxylic acid|CS-0042145](https://file.chemscene.com/productPIC/CS-0042145.gif)
23967-57-9 - ~99%
-
In-stock
66490-33-3
References
-
Allen, Daniel; Callaghan, Owen; Cordier, Frederic L.; Dobson, David R.; Harris, John R.; Hotten, Terry M.; Owton, W. Martin; Rathmell, Richard E.; Wood, Virginia A. Tetrahedron Letters, 2004 , vol. 45, # 52 p. 9645 - 9647
-
-
Route2
-
180160-64-9 - ~40%
-
In-stock
![6-Chlorobenzo[b]thiophene|CS-0119377](https://file.chemscene.com/productPIC/CS-0119377.gif)
66490-20-8 -
In-stock
66490-33-3
-
19742-92-8
References
-
Hansen, Marvin Martin; He, John Xiaoqiang; Honigschmidt, Nicholas Allan; Koch, Daniel James; Kohn, Todd Jonathan; Rocco, Vincent Patrick; Spinazze, Patrick Gianpietro; Takeuchi, Kumiko Patent: US2004/6229 A1, 2004 ; Location in patent: Page/Page column 38 ; US 20040006229 A1
-
-
Route3
-
205054-85-9 - ~%
-
In-stock
66490-20-8
-
In-stock
66490-33-3
References
-
AVENTIS PHARMACEUTICALS INC. Patent: US2004/102450 A1, 2004 ; Location in patent: Page/Page column 68 ;
-
Safety Information
Download SDS|
GHS Pictogram :
|
GHS No : GHS07
|
|
Signal Word : Warning
|
UN#: N/A
|
|
Class : N/A
|
Packing Group : N/A
|
|
Hazard Statements : H302-H315-H319-H335
|
|
|
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
|
|
Quality Control
Computational Chemistry Data
- TPSA 0
- LogP 3.5547
- H_Acceptors 1
- H_Donors 0
- Rotatable_Bonds 0
Similar Products
Other Classifications
Recently Viewed Products
Leave US a Message
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Upload Pictures
|
|
Key Words
- 4-Chlorobenzo[b]thiophene sigma4-Chlorobenzo[b]thiophene manufacturer4-Chlorobenzo[b]thiophene price4-Chlorobenzo[b]thiophene structure4-Chlorobenzo[b]thiophene SDSbuy 4-Chlorobenzo[b]thiophene4-Chlorobenzo[b]thiophene supplier4-Chlorobenzo[b]thiophene uses4-Chlorobenzo[b]thiophene molecular weightprice of 4-Chlorobenzo[b]thiophene4-Chlorobenzo[b]thiophene chemical name formula of 4-Chlorobenzo[b]thiophene