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CS-W001157 4
Total: USD 88.00

7-Chlorobenzo[b]thiophene

  • CAS No. 90407-14-0

  • Cat. No. CS-B1087
  • Purity≥95%
  • MDL No.MFCD00130097

*For research and further manufacturing use only, not for direct human use.

7-Chlorobenzo[b]thiophene|CS-B1087

Structure of 90407-14-0

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General Information

  • CAS No. 90407-14-0
  • Cat. No. CS-B1087
  • Purity ≥95%
  • MDL No. MFCD00130097
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₅ClS
  • Molecular Weight None
  • Synonym(s) 7-CHLORO-BENZO[B]THIOPHENE
  • SMILES ClC1=C2C(C=CS2)=CC=C1

Description

7-Chlorobenzo[b]thiophene is a heterocyclic scaffold featuring a chlorine substituent at the 7-position, offering enhanced electron deficiency and improved metabolic stability. This structural motif integrates readily into bioactive molecules, serving as a key building block in pharmaceutical development and materials science.

Application

7-Chlorobenzo[b]thiophene serves as a versatile heterocyclic building block in medicinal chemistry and materials science. Its electron-deficient aromatic core enables efficient transition-metal-catalyzed coupling reactions, particularly Suzuki-Miyaura and Stille couplings. The chloro substituent offers predictable regioselectivity and facilitates downstream functionalization. Bench-stable and readily purified by column chromatography, it functions reliably in multi-step syntheses of bioactive molecules and conjugated polymers.

Synthesis

  • Route1
    • (2-Chlorophenyl)(2,2-diethoxyethyl)sulfane|CS-0679105
      936902-05-5
    • ~95%
    • In-stock
      7-Chlorobenzo[b]thiophene|CS-B1087
      90407-14-0

    References

    • Dahnke, Karl Robert; Lin, Ho-Shen; Richett, Michael Enrico; Shih, Chuan; Wang, Q May; Zhang, Bo Patent: US2008/306082 A1, 2008 ; Location in patent: Page/Page column 26 ;
  • Route2
    • null|null
      90407-13-9
    • ~90%
    • In-stock
      7-Chlorobenzo[b]thiophene|CS-B1087
      90407-14-0

    References

    • Rahman, Loay K. A.; Scrowston, Richard M. Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1984 , # 3 p. 385 - 390
  • Route3
    • null|null
      101495-16-3
    • ~%
    • In-stock
      7-Chlorobenzo[b]thiophene|CS-B1087
      90407-14-0

    References

    • Journal of the American Chemical Society, , vol. 78, p. 6174,6176

Safety Information

Download SDS
GHS Pictogram : N/A
GHS No : N/A
Signal Word : N/A
UN#: 1760
Class : 8
Packing Group : Ⅲ
Hazard Statements : N/A
Precautionary Statements : N/A

Quality Control

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Computational Chemistry Data

  • TPSA   0
  • LogP   3.5547
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

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