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CS-W001157 4
Total: USD 88.00

(S)-(1-Methylpyrrolidin-2-yl)methanamine

  • CAS No. 66411-54-9

  • Cat. No. CS-0053063
  • Molecule weight114.19
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

(S)-(1-Methylpyrrolidin-2-yl)methanamine|CS-0053063

Structure of 66411-54-9

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General Information

  • CAS No. 66411-54-9
  • Cat. No. CS-0053063
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₁₄N₂
  • Molecular Weight 114.19
  • Synonym(s) 1-[(2S)-1-Methyl-2-pyrrolidinyl]methanamine
  • SMILES CN1CCC[C@H]1CN

Description

(S)-(1-Methylpyrrolidin-2-yl)methanamine is a chiral amine scaffold featuring a sterically defined pyrrolidine ring with a methylated nitrogen and a methylene-linked amine. This configuration imparts enhanced solubility and directional reactivity, enabling efficient coupling in asymmetric synthesis. The molecule serves as a modular building block for bioactive compound libraries, particularly in medicinal chemistry applications requiring precise stereocontrol.

Application

(S)-(1-Methylpyrrolidin-2-yl)methanamine serves as a versatile chiral building block in medicinal chemistry, enabling the synthesis of bioactive molecules through amine-based coupling reactions. Its pyrrolidine core provides favorable solubility and metabolic stability, while the (S)-configuration ensures stereochemical fidelity in target compounds. The molecule exhibits bench stability, ease of purification, and compatibility with standard functional group transformations, making it ideal for use in API development and fragment-based drug discovery workflows.

Synthesis

  • Route1

    References

    • Sassaman, Mark B.; Giovanelli, John; Sood, Virendar K.; Eckelman, William C. Bioorganic and Medicinal Chemistry, 1998 , vol. 6, # 10 p. 1759 - 1766
  • Route2

    References

    • Bioorganic and Medicinal Chemistry, , vol. 6, # 10 p. 1759 - 1766

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS02,GHS05
Signal Word : Danger
UN#: 2924
Class : 3,8
Packing Group : Ⅲ
Hazard Statements : H225-H314
Precautionary Statements : P210-P233-P240-P241-P242-P243-P260-P264-P280-P301+P330+P331-P304+P340-P363-P370+P378-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   29.26
  • LogP   0.0393
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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