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CS-W001157 4
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(S)-(1-Methylpyrrolidin-2-yl)methanamine dihydrochloride

  • CAS No. 219320-28-2

  • Cat. No. CS-0128648
  • Molecule weight187.11
  • Purity≥97%
  • MDL No.MFCD27996814

*For research and further manufacturing use only, not for direct human use.

(S)-(1-Methylpyrrolidin-2-yl)methanamine dihydrochloride|CS-0128648

Structure of 219320-28-2

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General Information

  • CAS No. 219320-28-2
  • Cat. No. CS-0128648
  • Purity ≥97%
  • MDL No. MFCD27996814
  • Storage 4°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₁₆Cl₂N₂
  • Molecular Weight 187.11
  • Synonym(s) Pyrrolidine, 2-(MethylaMinoMethyl)
  • SMILES NC[C@H]1N(C)CCC1.[H]Cl.[H]Cl

Description

(S)-(1-Methylpyrrolidin-2-yl)methanamine dihydrochloride is a chiral amine scaffold featuring a pyrrolidine ring with stereocontrolled methyl and amino substituents. This bench-stable, moisture-tolerant derivative delivers enhanced solubility and nucleophilicity in synthetic transformations. It serves as a key building block in asymmetric synthesis, enabling efficient access to bioactive amines and pharmaceutical intermediates through direct coupling or functional group interconversion.

Application

(S)-(1-Methylpyrrolidin-2-yl)methanamine dihydrochloride serves as a chiral building block for medicinal chemistry, enabling efficient access to nitrogen-containing scaffolds via standard amine coupling and reductive amination protocols. The dihydrochloride salt enhances bench stability and solubility, facilitating purification and handling in high-throughput synthesis workflows. Its well-defined stereochemistry supports consistent enantioselective transformations in API development.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   29.26
  • LogP   0.8829
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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