Imidazo[1,2-a]pyridin-5-amine

Name: Imidazo[1,2-a]pyridin-5-amine
Brand: ChemScene
Availability: InStock
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CAS No. 66358-23-4
Cat. No. CS-W019813
Purity≥98%
MDL No.MFCD05863377

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Imidazo[1,2-a]pyridin-5-amine|CS-W019813

Structure of 66358-23-4

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General Information

CAS No. 66358-23-4
Cat. No. CS-W019813
Purity ≥98%
MDL No. MFCD05863377
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₇H₇N₃
Molecular Weight 133.15
Synonym(s) Imidazo[1,2-a]pyridin-5-ylamine
SMILES NC1=CC=CC2=NC=CN12

Description

Imidazo[1,2-a]pyridin-5-amine delivers a rigid, electron-rich heterocyclic scaffold ideal for medicinal chemistry and materials science. This bench-stable core integrates seamlessly into kinase inhibitors and ligands for transition metal catalysis, offering enhanced solubility and predictable binding geometry in synthetic workflows.

Application

Imidazo[1,2-a]pyridin-5-amine serves as a versatile heterocyclic building block in medicinal chemistry, enabling efficient access to bioactive scaffolds. Its nitrogen-rich framework exhibits favorable solubility and stability, facilitating direct incorporation into diverse coupling reactions. The amine functionality supports straightforward derivatization via acylation, alkylation, or transition-metal-catalyzed transformations, making it a practical component in the synthesis of kinase inhibitors and CNS-targeted compounds.

Synthesis

Route1
- 107-20-0
- In-stock
  
  141-86-6
- ~81%
- In-stock
  
  66358-23-4
References
- TAKEDA PHARMACEUTICAL COMPANY LIMITED Patent: WO2005/44793 A2, 2005 ; Location in patent: Page/Page column 153-154 ; WO 2005/044793 A2

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302+H312+H332-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 43.32
LogP 0.9165
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 0

Other Classifications

Building Blocks Skeleton Aromatic heterocycle compounds Imidazole compounds

Key Words

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Imidazo[1,2-a]pyridin-5-amine

CAS No. 66358-23-4

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