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CS-W001157 4
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6-Methoxy-4-methylpyridin-3-amine

  • CAS No. 6635-91-2

  • Cat. No. CS-W005237
  • Purity≥97%
  • MDL No.MFCD08277274

*For research and further manufacturing use only, not for direct human use.

6-Methoxy-4-methylpyridin-3-amine|CS-W005237

Structure of 6635-91-2

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General Information

  • CAS No. 6635-91-2
  • Cat. No. CS-W005237
  • Purity ≥97%
  • MDL No. MFCD08277274
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₁₀N₂O
  • Molecular Weight 138.17
  • Synonym(s) 5-Amino-2-methoxy-4-picoline
  • SMILES COC1=CC(C)=C(N)C=N1

Description

6-Methoxy-4-methylpyridin-3-amine features a pyridine core functionalized with methoxy and methyl groups at the 6- and 4-positions, respectively, and an amine at the 3-position. This electron-rich scaffold delivers enhanced solubility and stability under standard conditions, enabling direct incorporation into medicinal chemistry libraries and catalyst design workflows.

Application

6-Methoxy-4-methylpyridin-3-amine serves as a versatile building block in medicinal chemistry, enabling efficient access to functionalized pyridine scaffolds. Its ortho-directing amino group and compatible methoxy/methyl substituents facilitate palladium-catalyzed cross-couplings, electrophilic substitutions, and further derivatization. The compound exhibits good bench stability and is readily purified by standard chromatographic methods, supporting its use in iterative synthesis campaigns for API candidates and heterocyclic libraries.

Synthesis

  • Route1

    References

    • Journal of the Chemical Society, <1954> 2448, 2451

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   48.14
  • LogP   0.98082
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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