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CS-W001157 4
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6-Hydroxy-5-nitronicotinic acid

  • CAS No. 6635-31-0

  • Cat. No. CS-W002917
  • Purity≥95%
  • MDL No.MFCD02180840

*For research and further manufacturing use only, not for direct human use.

6-Hydroxy-5-nitronicotinic acid|CS-W002917

Structure of 6635-31-0

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General Information

  • CAS No. 6635-31-0
  • Cat. No. CS-W002917
  • Purity ≥95%
  • MDL No. MFCD02180840
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₄N₂O₅
  • Molecular Weight 184.11
  • Synonym(s) 6-Hydroxy-5-nitro-3-pyridinecarboxylic Acid
  • SMILES O=C(C(C=C1[N+]([O-])=O)=CNC1=O)O

Description

6-Hydroxy-5-nitronicotinic acid features a hydroxyl group at the 6-position and a nitro substituent at the 5-position on a nicotinic acid scaffold. This combination imparts enhanced solubility and electron-withdrawing character, enabling its use in bioconjugation and medicinal chemistry applications. The molecule exhibits stability under standard bench conditions.

Application

6-Hydroxy-5-nitronicotinic acid serves as a versatile building block for heterocyclic synthesis, enabling efficient access to bioactive scaffolds through its complementary hydroxyl and nitro functional groups. The molecule exhibits bench stability and facilitates selective transformations under standard conditions, supporting diverse coupling reactions and derivatization strategies in medicinal chemistry workflows.

Synthesis

  • Route1
    • 6-Hydroxynicotinic acid Avatrombopag Impurity|CS-0377520
      5006-66-6
    • ~47%
    • In-stock
      6-Hydroxy-5-nitronicotinic acid|CS-W002917
      6635-31-0

    References

    • Linn, James A.; Gerritz, Samuel W.; Handlon, Anthony L.; Hyman, Clifton E.; Heyer, Dennis Tetrahedron Letters, 1999 , vol. 40, # 12 p. 2227 - 2230

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   113.3
  • LogP   -0.0187
  • H_Acceptors   4
  • H_Donors   2
  • Rotatable_Bonds   2

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