6-(4-Methylpiperazin-1-yl)pyridazin-3-amine

Name: 6-(4-Methylpiperazin-1-yl)pyridazin-3-amine
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 66346-94-9
Cat. No. CS-0151071
Molecule weight193.25
Purity≥97%
MDL No.MFCD13192341

HazMat Fee +

HazMat Fee

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

The shipment is processed through FedEx Ground under the Limited Quantity option.

Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

6-(4-Methylpiperazin-1-yl)pyridazin-3-amine|CS-0151071

Structure of 66346-94-9

Size

Price

Quantity

* Please select Quantity before adding items.

General Information

CAS No. 66346-94-9
Cat. No. CS-0151071
Purity ≥97%
MDL No. MFCD13192341
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₉H₁₅N₅
Molecular Weight 193.25
Synonym(s) None
SMILES CN1CCN(CC1)C2=NNC(=N)C=C2

Description

6-(4-Methylpiperazin-1-yl)pyridazin-3-amine features a pyridazin-3-amine core functionalized with a 4-methylpiperazine moiety, delivering enhanced solubility and metabolic stability. This electron-rich heterocycle integrates readily into kinase inhibitor scaffolds, where the piperazine group enables hydrogen bonding and improves pharmacokinetic profile. The compound exhibits bench-stable handling under standard conditions.

Application

6-(4-Methylpiperazin-1-yl)pyridazin-3-amine serves as a versatile heterocyclic building block in medicinal chemistry, enabling the synthesis of kinase inhibitors and other bioactive molecules. Its pyridazinamine core facilitates hydrogen bonding and π-stacking interactions, while the 4-methylpiperazine moiety offers favorable solubility and metabolic stability. The compound exhibits bench stability and compatibility with standard coupling reactions, supporting efficient functionalization in multi-step syntheses.

Synthesis

Route1
- In-stock
  
  109-01-3
- In-stock
  
  5469-69-2
- ~51%
- In-stock
  
  66346-94-9
References
- Tsou, Hwei-Ru; Otteng, Mercy; Tran, Tritin; Floyd Jr., M. Brawner; Reich, Marvin; Birnberg, Gary; Kutterer, Kristina; Ayral-Kaloustian, Semiramis; Ravi, Malini; Nilakantan, Ramaswamy; Grillo, Mary; McGinnis, John P.; Rabindran, Sridhar K. Journal of Medicinal Chemistry, 2008 , vol. 51, # 12 p. 3507 - 3525

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302
Precautionary Statements : P264-P270-P330-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

TPSA 59.01
LogP -0.35903
H_Acceptors 4
H_Donors 2
Rotatable_Bonds 1

Other Classifications

Building Blocks Skeleton Aromatic heterocycle compounds Pyridazine compounds

Building Blocks Skeleton Aliphatic heterocycle compounds Piperazine compounds

Key Words

66346-94-9 sigma66346-94-9 manufacturer66346-94-9 price66346-94-9 structure66346-94-9 SDSbuy 66346-94-966346-94-9 supplier66346-94-9 uses66346-94-9 molecular weightprice of 66346-94-966346-94-9 chemical name formula of 66346-94-9

Salutation:	*Country or Region:
*Applicant Name:	*Organization Name:
*Email Address:	Quantity:
CAS NO. :	Product Name:
Remarks:
Upload Pictures

CAS.No.		Product Name
Applicant Name *		Email Address *
Phone Number *		Organization Name*
Country or Region*		Quantity*
Remarks:

Product Name:
Cat. No.: .		CAS NO. :
Quantity:

6-(4-Methylpiperazin-1-yl)pyridazin-3-amine

CAS No. 66346-94-9

Recommended Products