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CS-W001157 4
Total: USD 88.00

4-((6,7-Dimethoxyquinolin-4-yl)oxy)aniline Cabozantinib Impurity

  • CAS No. 190728-25-7

  • Cat. No. CS-0167016
  • Purity≥98%
  • MDL No.MFCD19685633

*For research and further manufacturing use only, not for direct human use.

4-((6,7-Dimethoxyquinolin-4-yl)oxy)aniline  Cabozantinib Impurity|CS-0167016

Structure of 190728-25-7

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General Information

  • CAS No. 190728-25-7
  • Cat. No. CS-0167016
  • Purity ≥98%
  • MDL No. MFCD19685633
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₇H₁₆N₂O₃
  • Molecular Weight 296.33
  • Synonym(s) None
  • SMILES NC1=CC=C(OC2=CC=NC3=CC(OC)=C(OC)C=C23)C=C1

Synthesis

  • Route1
    • 6,7-dimethoxy-4-(4-nitrophenoxy)quinoline  Cabozantinib Impurity|CS-0166296
      190728-24-6
    • ~99%
    • In-stock
      4-((6,7-Dimethoxyquinolin-4-yl)oxy)aniline  Cabozantinib Impurity|CS-0167016
      190728-25-7

    References

    • Raeppel, Stephane; Claridge, Stephen William; Saavedra, Oscar Mario; Vaisburg, Arkadii; Deziel, Robert; Zhan, Lijie; Mannion, Michael; Gaudette, Frederic; Zhou, Nancy Z.; Isakovic, Ljubomir Patent: US2008/4273 A1, 2008 ; Location in patent: Page/Page column 86 ; US 20080004273 A1
  • Route2

    References

    • Shimizu, Toshiyuki; Fujiwara, Yasunari; Osawa, Tatsushi; Sakai, Teruyuki; Kubo, Kinya; Kubo, Kazuo; Nishitoba, Tsuyoshi; Kimura, Kaname; Senga, Terufumi; Murooka, Hideko; Iwai, Akemi; Fukushima, Kayoko; Yoshino, Tetsuya; Miwa, Atsushi Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 4 p. 875 - 879
  • Route3
    • 6,7-dimethoxy-1H-quinolin-4-one|CS-0039799
      127285-54-5
    • ~%
    • In-stock
      4-((6,7-Dimethoxyquinolin-4-yl)oxy)aniline  Cabozantinib Impurity|CS-0167016
      190728-25-7

    References

    • Kubo, Kazuo; Ohyama, Shin-Ichi; Shimizu, Toshiyuki; Takami, Atsuya; Murooka, Hideko; Nishitoba, Tsuyoshi; Kato, Shinichiro; Yagi, Mikio; Kobayashi, Yoshiko; Iinuma, Noriko; Isoe, Toshiyuki; Nakamura, Kazuhide; Iijima, Hiroshi; Osawa, Tatsushi; Izawa, Toshio Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 23 p. 5117 - 5133

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   66.6
  • LogP   3.6265
  • H_Acceptors   5
  • H_Donors   1
  • Rotatable_Bonds   4

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