Lot numbers can be found on the outside label of a product:
4-Chloro-6,7-dimethoxyquinoline
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CAS No. 35654-56-9
- Cat. No. CS-D1175
- Purity≥98%
- MDL No.MFCD07778437
*For research and further manufacturing use only, not for direct human use.
Structure of 35654-56-9
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General Information
- CAS No. 35654-56-9
- Cat. No. CS-D1175
- Purity ≥98%
- MDL No. MFCD07778437
- Storage 4°C
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₁₁H₁₀ClNO₂
- Molecular Weight 223.66
- Synonym(s) Oro-6,7-dimethoxyquinol
- SMILES COC1=C(OC)C=C2C(Cl)=CC=NC2=C1
Description
4-Chloro-6,7-dimethoxyquinoline is a heterocyclic scaffold featuring electron-rich methoxy groups at the 6 and 7 positions, enhancing its reactivity in cross-coupling transformations. The chlorine substituent at the 4-position enables efficient palladium-catalyzed coupling, making this compound valuable for constructing complex quinoline-based architectures in medicinal chemistry and materials science.
Application
4-Chloro-6,7-dimethoxyquinoline serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its reactive chlorine substituent. The dimethoxy groups enhance solubility and modulate electronic properties, while the quinoline core provides a stable scaffold for further functionalization. This compound exhibits bench stability and facilitates efficient purification, making it well-suited for iterative synthesis of heterocyclic compounds and potential API intermediates.
Synthesis
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Route1
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13425-93-9 - ~83%
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In-stock
35654-56-9
References
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XI, Ning; WANG, Tingjin; ZENG, Shan; SUN, Mingming; WANG, Kunrui Patent: WO2013/180949 A1, 2013 ; Location in patent: Paragraph 0170 ;
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Route2
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127285-54-5 - ~87%
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In-stock
35654-56-9
References
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KIRIN BEER KABUSHIKI KAISHA Patent: EP1559715 A1, 2005 ; Location in patent: Page/Page column 19 ;
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Route3
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67000-01-5 - ~%
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In-stock
35654-56-9
References
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US2012/70368 A1, ; US 20120070368 A1
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 31.35
- LogP 2.9054
- H_Acceptors 3
- H_Donors 0
- Rotatable_Bonds 2
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Key Words
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