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CS-W001157 4
Total: USD 88.00

1-(tert-Butoxycarbonyl)-4-oxopiperidine-2-carboxylic acid

  • CAS No. 661458-35-1

  • Cat. No. CS-0028400
  • Purity≥95%
  • MDL No.None
  • HazMat Fee +

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    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

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*For research and further manufacturing use only, not for direct human use.

1-(tert-Butoxycarbonyl)-4-oxopiperidine-2-carboxylic acid|CS-0028400

Structure of 661458-35-1

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Description

1-(tert-Butoxycarbonyl)-4-oxopiperidine-2-carboxylic acid features a protected piperidine scaffold with orthogonal functionality, enabling direct incorporation into peptide synthesis. The ketone and carboxylic acid moieties offer complementary reactivity for late-stage diversification. This bench-stable derivative facilitates efficient access to bioactive cyclic scaffolds in medicinal chemistry campaigns.

Application

1-(tert-Butoxycarbonyl)-4-oxopiperidine-2-carboxylic acid serves as a versatile building block in medicinal chemistry, enabling the synthesis of piperidine-based scaffolds prevalent in bioactive molecules. The protected amine and keto-carboxylic acid functionalities offer orthogonal reactivity for peptide coupling and selective reductions, while the tert-butyl carbamate group ensures stability during storage and standard synthetic manipulations. Its bench-stable nature and compatibility with common purification methods facilitate efficient route design for drug discovery campaigns.

General Information

  • CAS No. 661458-35-1
  • Cat. No. CS-0028400
  • Purity ≥95%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₁₇NO₅
  • Molecular Weight 243.26
  • Synonym(s) (R)-1-Boc-4-piperidone-2-carboxylic acid
  • SMILES O=C(N1C(C(O)=O)CC(CC1)=O)OC(C)(C)C

Computational Chemistry Data

  • TPSA   83.91
  • LogP   1.0396
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   1

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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