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Structure of 66021-95-2
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1-Ethynyl-2-isopropoxybenzene features a terminal alkyne group flanked by an electron-rich aromatic ring and a sterically hindered isopropoxy substituent. This configuration enables efficient copper-catalyzed coupling reactions under mild conditions, delivering robust C–C bond formation with high chemoselectivity. The molecule exhibits excellent bench stability and solubility in common organic solvents, facilitating its integration into complex synthetic sequences.
1-Ethynyl-2-isopropoxybenzene serves as a versatile building block for Sonogashira coupling reactions, enabling efficient access to substituted biaryls and conjugated systems. The terminal alkyne functionality exhibits high reactivity under palladium-catalyzed conditions, while the isopropoxy group provides moderate electron-donating character and enhanced stability compared to simpler alkoxides. Its bench-stable nature and compatibility with common protecting groups facilitate integration into multi-step synthetic sequences, particularly in the construction of functionalized aromatic scaffolds relevant to pharmaceutical and materials chemistry.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: