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CS-W001157 4
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5-Methyl-2-pyridinesulfonamide

  • CAS No. 65938-77-4

  • Cat. No. CS-W017596
  • Purity≥98%
  • MDL No.MFCD00661363

*For research and further manufacturing use only, not for direct human use.

5-Methyl-2-pyridinesulfonamide|CS-W017596

Structure of 65938-77-4

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General Information

  • CAS No. 65938-77-4
  • Cat. No. CS-W017596
  • Purity ≥98%
  • MDL No. MFCD00661363
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₈N₂O₂S
  • Molecular Weight 172.20
  • Synonym(s) 5-Methyl-2-pyridinesulfonamid
  • SMILES CC1=CN=C(C=C1)[S](=O)(=O)N

Description

5-Methyl-2-pyridinesulfonamide features a pyridine ring bearing a methyl group at the 5-position and a sulfonamide moiety at the 2-position, delivering enhanced solubility and stability. This scaffold integrates readily into bioactive molecules, serving as a key pharmacophore in kinase inhibitor design and other medicinal chemistry applications.

Application

5-Methyl-2-pyridinesulfonamide serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocycles through standard coupling and functionalization reactions. Its pyridine sulfonamide core exhibits favorable bench stability, moderate solubility, and compatibility with common protecting group strategies. The methyl substituent enhances lipophilicity and provides a handle for further derivatization, while the sulfonamide group offers strong hydrogen-bonding capacity and metabolic stability, making it a practical scaffold for targeted compound libraries.

Synthesis

  • Route1
    • null|null
      1336-21-6
    • null|null
      96042-30-7
    • In-stock
      5-Methylpyridine-2(1H)-thione|CS-0152866
      18368-58-6
    • ~%
    • In-stock
      5-Methyl-2-pyridinesulfonamide|CS-W017596
      65938-77-4

    References

    • US2003/87920 A1, ;
  • Route2
    • In-stock
      2-Bromo-5-methylpyridine|CS-W007353
      3510-66-5
    • null|null
      13598-45-3
    • null|null
      110-18-9
    • null|null
      7446-09-5
    • ~%
    • In-stock
      5-Methyl-2-pyridinesulfonamide|CS-W017596
      65938-77-4

    References

    • US6017945 A1, ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   73.05
  • LogP   0.03742
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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