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Structure of 657-46-5
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1-Fluoro-3-(methylsulfonyl)benzene features a fluorine atom ortho to a methylsulfonyl group on a benzene ring, delivering enhanced electron-withdrawing character and improved metabolic stability. This combination enables selective electrophilic substitution and facilitates incorporation into pharmaceutical scaffolds requiring controlled reactivity and solubility under standard conditions.
1-Fluoro-3-(methylsulfonyl)benzene serves as a versatile aryl fluorosulfone building block, enabling palladium-catalyzed cross-coupling reactions with high functional group tolerance. The meta-fluoro and methylsulfonyl groups provide orthogonal reactivity, facilitating sequential transformations in complex molecule synthesis. Bench-stable and readily purified by chromatography, it functions effectively in Suzuki-Miyaura and Negishi coupling protocols for constructing biaryl and heterocyclic scaffolds common in medicinal chemistry.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P280-P302+P352
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Lot numbers can be found on the outside label of a product: