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CS-W001157 4
Total: USD 88.00

4-Fluorophenyl methyl sulfone

  • CAS No. 455-15-2

  • Cat. No. CS-W002183
  • Purity≥98%
  • MDL No.MFCD00039753

*For research and further manufacturing use only, not for direct human use.

4-Fluorophenyl methyl sulfone|CS-W002183

Structure of 455-15-2

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General Information

  • CAS No. 455-15-2
  • Cat. No. CS-W002183
  • Purity ≥98%
  • MDL No. MFCD00039753
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₇FO₂S
  • Molecular Weight 174.19
  • Synonym(s) Sulfone, p-fluorophenyl methyl
  • SMILES Fc1ccc(cc1)S(=O)(=O)C

Description

4-Fluorophenyl methyl sulfone was used in the preparation of 4-(4-trifluoromethoxyphenoxy)phenyl methyl sulfone.

Application

4-Fluorophenyl methyl sulfone serves as a versatile building block in medicinal chemistry, enabling the introduction of a polar, electron-withdrawing group with enhanced metabolic stability. Its bench-stable nature and compatibility with Suzuki-Miyaura and Buchwald-Hartwig coupling reactions facilitate efficient construction of biaryl and aryl-amine scaffolds commonly found in pharmaceutical intermediates.

Synthesis

  • Route1
    • null|null
      462-06-6
    • ~99%
    • In-stock
      4-Fluorophenyl methyl sulfone|CS-W002183
      455-15-2

    References

    • Dubac, Jacques; Le Roux, Christophe; Repichet, Sigrid; Roques, Nicolas; Bernard, Jean-Marie; Maestro, Jean-Pierre; Vidal, Thierry; Peyronneau, Magali; Picot, Alexandre; Mazieres, Stephane Patent: US2004/116733 A1, 2004 ; Location in patent: Page 11-12 ;
  • Route2

    References

    • ASTRAZENECA AB Patent: WO2008/147314 A1, 2008 ; Location in patent: Page/Page column 85; 86 ; WO 2008/147314 A1
  • Route3

    References

    • Maity, Niladri; Wattanakit, Chularat; Muratsugu, Satoshi; Ishiguro, Nozomu; Yang, Yong; Ohkoshi, Shin-Ichi; Tada, Mizuki Dalton Transactions, 2012 , vol. 41, # 15 p. 4558 - 4565

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   34.14
  • LogP   1.2292
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

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