Tel:

Email:

EN
Cat. No. Size / Unit Price Qty
CS-W001157 4
Total: USD 88.00

2,2-Difluorobenzo[d][1,3]dioxole-5-carboxylic acid

  • CAS No. 656-46-2

  • Cat. No. CS-W015523
  • Purity≥97%
  • MDL No.MFCD00792417

*For research and further manufacturing use only, not for direct human use.

2,2-Difluorobenzo[d][1,3]dioxole-5-carboxylic acid|CS-W015523

Structure of 656-46-2

Please choose your location and provide accurate information for you
Size Stock
Price Quantity

* Please select Quantity before adding items.

General Information

  • CAS No. 656-46-2
  • Cat. No. CS-W015523
  • Purity ≥97%
  • MDL No. MFCD00792417
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₄F₂O₄
  • Molecular Weight 202.11
  • Synonym(s) 2,2-Difluoro-1,3-benzodioxole-5-carboxylic acid
  • SMILES OC(=O)C1=CC2=C(OC(F)(F)O2)C=C1

Description

This difluorinated benzo[d][1,3]dioxole carboxylic acid integrates a rigid, electron-deficient aromatic core with enhanced metabolic stability. The ortho-fluorine substitution pattern imparts favorable lipophilicity and resistance to enzymatic degradation, making it a valuable scaffold for bioactive molecule design.

Application

2,2-Difluorobenzo[d][1,3]dioxole-5-carboxylic acid serves as a versatile building block for the synthesis of fluorinated heterocyclic scaffolds. Its carboxylic acid functionality enables straightforward derivatization via amide, ester, or acyl chloride formation, while the ortho-difluoro substitution enhances metabolic stability and modulates electronic properties. The benzo[d][1,3]dioxole core provides structural rigidity and favorable lipophilicity, making it valuable in medicinal chemistry campaigns targeting CNS and kinase-directed therapeutics. The compound exhibits good bench stability and is compatible with standard coupling protocols.

Synthesis

  • Route1

    References

    • BIOENERGENIX Patent: US2012/277224 A1, 2012 ; Location in patent: Page/Page column 26 ; US 20120277224 A1
  • Route2

    References

    • Pleschke, Axel; Marhold, Albrecht Patent: US2005/277692 A1, 2005 ; Location in patent: Page/Page column 3 ;
  • Route3

    References

    • US2012/277224 A1, ; US 20120277224 A1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

  • TPSA   55.76
  • LogP   1.7063
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

Other Classifications

Recently Viewed Products

Leave US a Message
Upload Pictures

Key Words

  • 656-46-2 sigma656-46-2 manufacturer656-46-2 price656-46-2 structure656-46-2 SDSbuy 656-46-2656-46-2 supplier656-46-2 uses656-46-2 molecular weightprice of 656-46-2656-46-2 chemical name formula of 656-46-2
This product is not sold in the region.
Confirm
How to get a Lot Number

Lot numbers can be found on the outside label of a product:

ChemScene Label