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Structure of 654-98-8
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5-Chloro-2-(trifluoromethyl)benzoic acid features a strategically positioned trifluoromethyl group that enhances electron withdrawal and metabolic stability. The ortho-chloro substituent further modulates electronic properties, making this scaffold valuable for pharmaceutical intermediates and agrochemical development under standard conditions.
5-Chloro-2-(trifluoromethyl)benzoic acid serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling efficient access to substituted benzimidazoles, heterocycles, and bioactive scaffolds. Its orthogonal functional groups—chlorine and trifluoromethyl—facilitate palladium-catalyzed cross-couplings and electrophilic substitutions, while the carboxylic acid enables direct derivatization or salt formation. The compound exhibits excellent bench stability and compatibility with standard purification protocols, making it well-suited for high-throughput screening campaigns and process-scale applications.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P302+P352
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Lot numbers can be found on the outside label of a product: