8-Bromo-4-chloroquinoline

Name: 8-Bromo-4-chloroquinoline
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 65340-71-8
Cat. No. CS-W012763
Purity≥95%
MDL No.MFCD01861852

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Structure of 65340-71-8

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General Information

CAS No. 65340-71-8
Cat. No. CS-W012763
Purity ≥95%
MDL No. MFCD01861852
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₉H₅BrClN
Molecular Weight 242.50
Synonym(s) 8-Bromo-4-chloro-1-azanaphthalene
SMILES ClC1=CC=NC2=C(Br)C=CC=C12

Description

8-Bromo-4-chloroquinoline is a halogenated quinoline derivative featuring complementary reactive sites for cross-coupling and functionalization. The electron-deficient aromatic core pairs with the bromine and chlorine substituents to enable selective metal-mediated transformations. This scaffold delivers high stability under standard conditions and integrates readily into complex molecular architectures for medicinal chemistry and materials applications.

Application

8-Bromo-4-chloroquinoline serves as a versatile building block in medicinal chemistry, enabling direct incorporation into diverse heterocyclic scaffolds via palladium-catalyzed cross-coupling reactions. Its orthogonal halogenation pattern supports sequential functionalization, while the quinoline core provides inherent stability and favorable pharmacophoric properties for drug discovery applications.

Synthesis

Route1
- In-stock
  
  57798-00-2
- ~%
- In-stock
  
  65340-71-8
References
- TAIHO PHARMACEUTICAL CO., LTD.; Kitade, Makoto; Yamashita, Satoshi; Ohkubo, Shuichi Patent: US2013/296320 A1, 2013 ; Location in patent: Paragraph 0322 ;
Route2
- 615-36-1
- ~%
- In-stock
  
  65340-71-8
References
- US2013/296320 A1, ;

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS05,GHS06
Signal Word : Danger	UN#: 2811
Class : 6.1	Packing Group : Ⅲ
Hazard Statements : H301-H318
Precautionary Statements : P264-P270-P280-P330-P405-P501

Quality Control

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Computational Chemistry Data

TPSA 12.89
LogP 3.6507
H_Acceptors 1
H_Donors 0
Rotatable_Bonds 0

Other Classifications

Building Blocks Functional Group Bromide

Building Blocks Skeleton Aromatic heterocycle compounds quinoline compounds

Key Words

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8-Bromo-4-chloroquinoline

CAS No. 65340-71-8

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