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CS-W001157 4
Total: USD 88.00

3-Bromo-6-methylpyridazine

  • CAS No. 65202-58-6

  • Cat. No. CS-W019649
  • Purity≥98%
  • MDL No.MFCD09831907

*For research and further manufacturing use only, not for direct human use.

3-Bromo-6-methylpyridazine|CS-W019649

Structure of 65202-58-6

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General Information

  • CAS No. 65202-58-6
  • Cat. No. CS-W019649
  • Purity ≥98%
  • MDL No. MFCD09831907
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₅BrN₂
  • Molecular Weight 173.01
  • Synonym(s) Pyridazine, 3-bromo-6-methyl-
  • SMILES CC1=NN=C(Br)C=C1

Description

3-Bromo-6-methylpyridazine is a halogenated pyridazine derivative featuring a bromine atom at the 3-position and a methyl group at the 6-position. This electron-deficient heterocycle serves as a key building block in medicinal chemistry, enabling efficient coupling reactions for constructing complex nitrogen-containing scaffolds under standard conditions.

Application

3-Bromo-6-methylpyridazine serves as a versatile building block in medicinal chemistry, enabling direct functionalization at the pyridazine core via cross-coupling reactions. The bromine substituent facilitates palladium-catalyzed coupling with boronic acids and amines, while the methyl group enhances metabolic stability and modulates electronic properties. Its bench-stable crystalline form supports straightforward handling and purification, making it well-suited for modular synthesis of heterocyclic scaffolds relevant to drug discovery.

Synthesis

  • Route1

    References

    • WO2010/36998 A2, ; Page/Page column 184 ;
  • Route2
    • null|null
      157200-06-1
    • ~%
    • In-stock
      3-Bromo-6-methylpyridazine|CS-W019649
      65202-58-6

    References

    • US6265434 B1, ; US 6265434 B1
  • Route3
    • 6-Methylpyridazin-3(2H)-one Hydrobromide|CS-0152721
      94248-99-4
    • ~%
    • In-stock
      3-Bromo-6-methylpyridazine|CS-W019649
      65202-58-6

    References

    • Chemische Berichte, , vol. 81, p. 1,10

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   25.78
  • LogP   1.54752
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   0

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