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CS-W001157 4
Total: USD 88.00

2-[(4-methoxyphenyl)methylamino]ethanol

  • CAS No. 64834-63-5

  • Cat. No. CS-0037172
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2-[(4-methoxyphenyl)methylamino]ethanol|CS-0037172

Structure of 64834-63-5

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General Information

  • CAS No. 64834-63-5
  • Cat. No. CS-0037172
  • Purity ≥95%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₅NO₂
  • Molecular Weight 181.23
  • Synonym(s) 2-[[(4-METHOXYPHENYL)METHYL]AMINO]-ETHANOL
  • SMILES COC1=CC=C(C=C1)CNCCO

Description

2-((4-Methoxybenzyl)amino)ethanol features a benzyl-amino ethyl scaffold with a methoxy group that enhances solubility and electron-donating character. This amine derivative serves as a key building block in peptide conjugation and bioactive molecule synthesis, offering stability under standard conditions.

Application

2-((4-Methoxybenzyl)amino)ethanol serves as a versatile bifunctional building block in medicinal chemistry, enabling the synthesis of bioactive heterocycles and peptide conjugates. The pendant amine facilitates nucleophilic functionalization, while the methoxybenzyl group offers orthogonal protection and ease of removal under mild acidic conditions. Its bench-stable nature and compatibility with standard coupling reactions make it well-suited for modular library synthesis and API intermediate development.

Synthesis

  • Route1
    • 4-Methoxybenzaldehyde, ≥ 99% GC|CS-0676496
      123-11-5
    • null|null
      141-43-5
    • ~96%
    • In-stock
      2-[(4-methoxyphenyl)methylamino]ethanol|CS-0037172
      64834-63-5

    References

    • WO2010/65717 A1, ; Page/Page column 274; 275 ; WO 2010/065717 A1
  • Route2
    • null|null
      1952-35-8
    • ~%
    • In-stock
      2-[(4-methoxyphenyl)methylamino]ethanol|CS-0037172
      64834-63-5

    References

    • Journal of Medicinal Chemistry, , vol. 44, # 16 p. 2555 - 2564
  • Route3
    • 4-Methoxybenzaldehyde, ≥ 99% GC|CS-0676496
      123-11-5
    • ~%
    • In-stock
      2-[(4-methoxyphenyl)methylamino]ethanol|CS-0037172
      64834-63-5

    References

    • Journal of Medicinal Chemistry, , vol. 44, # 16 p. 2555 - 2564

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

Quality Control

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Computational Chemistry Data

  • TPSA   41.49
  • LogP   0.7771
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   5

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