4-Bromo-5-methoxyquinoline

Name: 4-Bromo-5-methoxyquinoline
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 643069-46-9
Cat. No. CS-0012679
Purity≥95%
MDL No.MFCD09261096

HazMat Fee +

HazMat Fee

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

The shipment is processed through FedEx Ground under the Limited Quantity option.

Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

Structure of 643069-46-9

Size

Price

Quantity

* Please select Quantity before adding items.

General Information

CAS No. 643069-46-9
Cat. No. CS-0012679
Purity ≥95%
MDL No. MFCD09261096
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₀H₈BrNO
Molecular Weight 238.08
Synonym(s) None
SMILES COC1=C2C(Br)=CC=NC2=CC=C1

Description

4-Bromo-5-methoxyquinoline is a heterocyclic building block featuring a bromine atom at the 4-position and a methoxy group at the 5-position of the quinoline core. This substitution pattern imparts enhanced solubility and electronic tunability, enabling efficient coupling in palladium-catalyzed cross-coupling reactions. The molecule exhibits bench-stable handling characteristics and serves as a key intermediate in the synthesis of bioactive compounds and functional materials.

Application

4-Bromo-5-methoxyquinoline serves as a versatile building block in medicinal chemistry and catalytic cross-coupling reactions. The bromine moiety enables reliable Suzuki, Stille, and Negishi couplings, while the methoxy group provides moderate electron-donating character and ortho-directing influence. Bench-stable and readily purified by column chromatography, it functions effectively in the synthesis of quinoline-based pharmaceuticals and functional materials.

Synthesis

Route1
- 643069-43-6
- ~85%
- In-stock
  
  643069-46-9
References
- GLAXO GROUP LIMITED Patent: WO2004/2992 A1, 2004 ; Location in patent: Page 80 ;

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

TPSA 22.12
LogP 3.0059
H_Acceptors 2
H_Donors 0
Rotatable_Bonds 1

Other Classifications

Building Blocks Skeleton Aromatic heterocycle compounds quinoline compounds

Key Words

4-Bromo-5-methoxyquinoline sigma4-Bromo-5-methoxyquinoline manufacturer4-Bromo-5-methoxyquinoline price4-Bromo-5-methoxyquinoline structure4-Bromo-5-methoxyquinoline SDSbuy 4-Bromo-5-methoxyquinoline4-Bromo-5-methoxyquinoline supplier4-Bromo-5-methoxyquinoline uses4-Bromo-5-methoxyquinoline molecular weightprice of 4-Bromo-5-methoxyquinoline4-Bromo-5-methoxyquinoline chemical name formula of 4-Bromo-5-methoxyquinoline

Salutation:	*Country or Region:
*Applicant Name:	*Organization Name:
*Email Address:	Quantity:
CAS NO. :	Product Name:
Remarks:
Upload Pictures

CAS.No.		Product Name
Applicant Name *		Email Address *
Phone Number *		Organization Name*
Country or Region*		Quantity*
Remarks:

Product Name:
Cat. No.: .		CAS NO. :
Quantity:

4-Bromo-5-methoxyquinoline

CAS No. 643069-46-9

Recommended Products