7-Bromo-5-methoxyquinoline

Name: 7-Bromo-5-methoxyquinoline
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 1378860-76-4
Cat. No. CS-B0550
Molecule weight238.08
Purity≥98%
MDL No.MFCD11878498

HazMat Fee +

HazMat Fee

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

The shipment is processed through FedEx Ground under the Limited Quantity option.

Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

Structure of 1378860-76-4

Size

Price

Quantity

* Please select Quantity before adding items.

General Information

CAS No. 1378860-76-4
Cat. No. CS-B0550
Purity ≥98%
MDL No. MFCD11878498
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₀H₈BrNO
Molecular Weight 238.08
Synonym(s) 7-bromo-5-methoxy-quinoline
SMILES BrC1=CC(OC)=C2C(N=CC=C2)=C1

Description

7-Bromo-5-methoxyquinoline is a halogenated quinoline derivative featuring a bromine atom at the 7-position and a methoxy group at the 5-position. This substitution pattern imparts enhanced electron-withdrawing character and improved solubility in organic solvents, facilitating its use in transition metal-catalyzed cross-coupling reactions. The molecule exhibits bench-stable handling under standard conditions and serves as a valuable scaffold for medicinal chemistry and materials science applications.

Application

7-Bromo-5-methoxyquinoline serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions for the construction of biaryl scaffolds. The bromine at C7 provides a reliable site for Suzuki, Stille, or Negishi coupling, while the methoxy group at C5 offers moderate electron donation and orthogonality to common protecting groups. Its bench-stable crystalline form facilitates handling and purification, making it well-suited for iterative synthesis in API development workflows.

Synthesis

Route1
- In-stock
  
  16618-68-1
- In-stock
  
  56-81-5
- ~27%
- In-stock
  
  1378860-76-4
- In-stock
  
  1126824-44-9
References
- BOEHRINGER INGELHEIM INTERNATIONAL GMBH; HOFFMANN, Matthias; BISCHOFF, Daniel; DAHMANN, Georg; KLICIC, Jasna; SCHAENZLE, Gerhard; WOLLIN, Stefan Ludwig Michael; CONVERS-REIGNIER, Serge Gaston; EAST, Stephen Peter; MARLIN, Frederic Jacques; MCCARTHY, Clive; SCOTT, John Patent: WO2013/14060 A1, 2013 ; Location in patent: Page/Page column 49 ; WO 2013/014060 A1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

TPSA 22.12
LogP 3.0059
H_Acceptors 2
H_Donors 0
Rotatable_Bonds 1

Other Classifications

Building Blocks Skeleton Aromatic heterocycle compounds quinoline compounds

Key Words

7-Bromo-5-methoxyquinoline sigma7-Bromo-5-methoxyquinoline manufacturer7-Bromo-5-methoxyquinoline price7-Bromo-5-methoxyquinoline structure7-Bromo-5-methoxyquinoline SDSbuy 7-Bromo-5-methoxyquinoline7-Bromo-5-methoxyquinoline supplier7-Bromo-5-methoxyquinoline uses7-Bromo-5-methoxyquinoline molecular weightprice of 7-Bromo-5-methoxyquinoline7-Bromo-5-methoxyquinoline chemical name formula of 7-Bromo-5-methoxyquinoline

Salutation:	*Country or Region:
*Applicant Name:	*Organization Name:
*Email Address:	Quantity:
CAS NO. :	Product Name:
Remarks:
Upload Pictures

CAS.No.		Product Name
Applicant Name *		Email Address *
Phone Number *		Organization Name*
Country or Region*		Quantity*
Remarks:

Product Name:
Cat. No.: .		CAS NO. :
Quantity:

7-Bromo-5-methoxyquinoline

CAS No. 1378860-76-4

Recommended Products