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Structure of 64224-65-3
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5-Chloropyrimidine-4-carboxylic acid features a chlorine-substituted pyrimidine core paired with a carboxylic acid group, enabling direct incorporation into bioactive scaffolds. The electron-deficient ring system facilitates nucleophilic substitution reactions, while the acidic functionality supports salt formation and conjugation. This compound serves as a key intermediate in medicinal chemistry for constructing heterocyclic frameworks with enhanced metabolic stability and target affinity.
5-Chloropyrimidine-4-carboxylic acid serves as a versatile building block in medicinal chemistry, enabling direct functionalization at the C4 position via nucleophilic substitution or coupling reactions. Its bench-stable nature and tolerance to common protecting groups facilitate integration into complex heterocyclic scaffolds. The carboxylic acid moiety supports derivatization for prodrug strategies or conjugation, while the chloro group provides a reliable handle for late-stage modification in API development workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: