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Structure of 641571-13-3
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This trifluoromethyl-substituted benzoic acid features a methyl-imidazole handle for bioconjugation, delivering enhanced solubility and stability in aqueous media. The electron-deficient aryl core enables efficient coupling reactions under standard conditions.
3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)benzoic acid serves as a versatile building block for medicinal chemistry campaigns, enabling rapid access to bioactive heterocyclic scaffolds. Its orthogonal functional groups—namely the carboxylic acid and electron-deficient trifluoromethyl-substituted aryl ring—facilitate downstream derivatization via amide coupling, esterification, or Suzuki-type cross-coupling. The imidazole moiety offers hydrogen-bonding capability and metabolic stability, enhancing ligand affinity in target-directed synthesis. Bench-stable and readily purified by recrystallization, it supports scalable, reproducible workflows in API development.
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: