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CS-W001157 4
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(1H-Indazol-3-yl)methanol

  • CAS No. 64132-13-4

  • Cat. No. CS-0052546
  • Purity≥96%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

(1H-Indazol-3-yl)methanol|CS-0052546

Structure of 64132-13-4

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General Information

  • CAS No. 64132-13-4
  • Cat. No. CS-0052546
  • Purity ≥96%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₈N₂O
  • Molecular Weight 148.16
  • Synonym(s) 1H-indazol-3-ylmethanol
  • SMILES OCC1=NNC2=CC=CC=C12

Description

This bench-stable indazolylmethanol features a polar hydroxymethyl group attached to an electron-rich heterocyclic core, enabling direct functionalization in late-stage synthesis. Its compatibility with diverse reaction conditions supports efficient integration into bioactive scaffolds and medicinal chemistry libraries.

Application

(1H-Indazol-3-yl)methanol serves as a versatile building block for medicinal chemistry and heterocyclic synthesis, enabling direct functionalization at the indazole core. Its benzylic alcohol functionality facilitates oxidation to carboxylic acids, substitution to form ethers or esters, and coupling reactions under standard conditions. The molecule exhibits good bench stability and compatibility with common protecting group strategies, making it well-suited for multi-step synthesis campaigns in API development.

Synthesis

  • Route1

    References

    • KYOWA HAKKO KOGYO CO., LTD. Patent: EP1878737 A1, 2008 ; Location in patent: Page/Page column 12 ;
  • Route2

    References

    • Journal of the American Chemical Society, , vol. 74, p. 2009,2010

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   48.91
  • LogP   1.0552
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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