Lot numbers can be found on the outside label of a product:
Methyl 1H-indazole-3-carboxylate
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CAS No. 43120-28-1
- Cat. No. CS-W020527
- Purity≥98%
- MDL No.MFCD01138133
*For research and further manufacturing use only, not for direct human use.
Structure of 43120-28-1
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General Information
- CAS No. 43120-28-1
- Cat. No. CS-W020527
- Purity ≥98%
- MDL No. MFCD01138133
- Storage Store at room temperature
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₉H₈N₂O₂
- Molecular Weight 176.17
- Synonym(s) 1H-indazole-3-carboxylic acid, methyl ester
- SMILES O=C(C1=NNC2=C1C=CC=C2)OC
Description
Methyl 1H-indazole-3-carboxylate is a bench-stable heterocyclic ester featuring a fused indazole core with a strategically positioned ester group. This compound serves as a key intermediate in the synthesis of bioactive molecules, particularly those targeting kinase pathways. The electron-deficient indazole ring facilitates transition metal-catalyzed coupling reactions, while the methyl ester enables selective derivatization under mild conditions.
Application
Methyl 1H-indazole-3-carboxylate serves as a versatile building block in medicinal chemistry, enabling direct functionalization at the indazole core for the synthesis of bioactive heterocycles. Its methyl ester group facilitates selective transformations, including hydrolysis, reduction, and coupling reactions, while the indazole scaffold offers excellent stability and compatibility with diverse reaction conditions. This compound functions as a key intermediate in constructing kinase inhibitors and other pharmaceutical scaffolds.
Synthesis
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Route1
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67-56-1 -
In-stock
4498-67-3 - ~98%
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In-stock
43120-28-1
References
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Tetrahedron Letters, , vol. 48, # 14 p. 2457 - 2460
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Route2
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In-stock
4498-67-3
- ~86%
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In-stock
43120-28-1
References
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US2006/47126 A1, ; Page/Page column 25 ;
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Route3
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67-56-1
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201230-82-2
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In-stock
66607-27-0 - ~89%
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In-stock
43120-28-1
References
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Synthesis, , # 19 art. no. T48411SS, p. 3089 - 3098
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 54.98
- LogP 1.3495
- H_Acceptors 3
- H_Donors 1
- Rotatable_Bonds 1
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Key Words
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