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Structure of 641-49-6
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1-Fluoro-3-methoxy-2-nitrobenzene features a strategically positioned nitro group that enhances electrophilicity at the ortho carbon, enabling efficient coupling in palladium-catalyzed reactions. The methoxy substituent improves solubility and stabilizes intermediates under standard conditions, while the fluorine atom facilitates directed metalation. This combination delivers high reactivity in C–H functionalization and cross-coupling workflows.
1-Fluoro-3-methoxy-2-nitrobenzene serves as a versatile ortho-functionalized aryl building block in synthetic organic chemistry. Its fluorine and nitro groups enable sequential functionalization via nucleophilic aromatic substitution and reduction, respectively. The methoxy group provides steric and electronic modulation, enhancing regioselectivity in coupling reactions. This compound exhibits bench stability and facilitates efficient access to substituted anilines and heterocyclic scaffolds commonly found in pharmaceutical intermediates.
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GHS No : GHS06,GHS08
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Signal Word : Danger
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UN#: 2811
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Class : 6.1
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Packing Group : Ⅲ
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Hazard Statements : H301-H315-H319-H335-H350
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Precautionary Statements : P264-P270-P330-P405-P501
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Lot numbers can be found on the outside label of a product: