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CS-W001157 4
Total: USD 88.00

5-Bromobenzo[d]oxazol-2-amine

  • CAS No. 64037-07-6

  • Cat. No. CS-W005168
  • Purity≥98%
  • MDL No.MFCD01664213

*For research and further manufacturing use only, not for direct human use.

5-Bromobenzo[d]oxazol-2-amine|CS-W005168

Structure of 64037-07-6

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General Information

  • CAS No. 64037-07-6
  • Cat. No. CS-W005168
  • Purity ≥98%
  • MDL No. MFCD01664213
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₅BrN₂O
  • Molecular Weight 213.03
  • Synonym(s) 2-Amino-5-brom-benzoxazol
  • SMILES NC1=NC2=CC(Br)=CC=C2O1

Description

5-Bromobenzo[d]oxazol-2-amine features a brominated oxazole core paired with an amino group at the 2-position, enabling direct functionalization in cross-coupling and cyclization reactions. The electron-deficient heterocycle integrates readily into bioactive scaffolds, offering enhanced metabolic stability and tunable solubility under standard conditions.

Application

5-Bromobenzo[d]oxazol-2-amine serves as a versatile building block for the synthesis of heterocyclic scaffolds in medicinal chemistry and materials science. Its bromine substituent enables palladium-catalyzed cross-coupling reactions, while the amino group provides a handle for derivatization via acylation, alkylation, or electrophilic substitution. The compound exhibits good bench stability and facilitates efficient functionalization under standard reaction conditions.

Synthesis

  • Route1
    • null|null
      506-68-3
    • In-stock
      2-Amino-4-bromophenol|CS-W007625
      40925-68-6
    • ~97%
    • In-stock
      5-Bromobenzo[d]oxazol-2-amine|CS-W005168
      64037-07-6

    References

    • INTELLIKINE, LLC; REN, Pingda; MARTIN, Michael Patent: WO2013/23184 A1, 2013 ; Location in patent: Paragraph 00231; 00232 ; WO 2013/023184 A1
  • Route2
    • null|null
      1404480-03-0
    • ~%
    • In-stock
      5-Bromobenzo[d]oxazol-2-amine|CS-W005168
      64037-07-6

    References

    • WO2010/51042 A1, ; Page/Page column 133 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   52.05
  • LogP   2.1725
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   0

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