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Structure of 640280-28-0
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1-Bromo-2-iodo-4-(trifluoromethyl)benzene features a strategically positioned trifluoromethyl group enhancing electron-withdrawal, while orthogonal halogens enable sequential cross-coupling. This dual-halo functionality supports modular diversification in medicinal chemistry and materials synthesis under standard conditions.
1-Bromo-2-iodo-4-(trifluoromethyl)benzene serves as a versatile diaryl building block for cross-coupling reactions, enabling sequential functionalization via orthogonal halogen reactivity. The bromo and iodo groups exhibit complementary reactivity in palladium-catalyzed coupling protocols, facilitating the construction of complex biaryl architectures with high regiocontrol. Its trifluoromethyl substituent enhances metabolic stability and lipophilicity, making it valuable for medicinal chemistry applications. The compound demonstrates excellent bench stability and compatibility with standard purification methods.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: