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CS-W001157 4
Total: USD 88.00

N,4-Dimethylbenzenesulfonamide

  • CAS No. 640-61-9

  • Cat. No. CS-W016946
  • Purity≥98%
  • MDL No.MFCD00008285

*For research and further manufacturing use only, not for direct human use.

N,4-Dimethylbenzenesulfonamide|CS-W016946

Structure of 640-61-9

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General Information

  • CAS No. 640-61-9
  • Cat. No. CS-W016946
  • Purity ≥98%
  • MDL No. MFCD00008285
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₁NO₂S
  • Molecular Weight 185.24
  • Synonym(s) N-methy-P-toluene sulfonamide
  • SMILES O=S(C1=CC=C(C)C=C1)(NC)=O

Description

N-Methyl-p-toluenesulfonamide was used in the synthesis of vicinal haloamino ketone derivative.

Application

N,4-Dimethylbenzenesulfonamide serves as a robust sulfonamide building block in medicinal chemistry, offering enhanced metabolic stability and improved solubility compared to unsubstituted analogs. Its methylated aromatic ring enhances lipophilicity and provides steric protection, facilitating downstream functionalization via electrophilic substitution. The compound exhibits excellent bench stability, ease of purification, and compatibility with standard coupling protocols, making it a practical choice for scaffold diversification in API development.

Synthesis

  • Route1
    • null|null
      1634-04-4
    • In-stock
      p-Toluenesulfonamide|CS-0012133
      70-55-3
    • ~22%
    • N-tert-Butyl-4-methylbenzenesulfonamide|CS-0098574
      2849-81-2
    • In-stock
      N,4-Dimethylbenzenesulfonamide|CS-W016946
      640-61-9

    References

    • Tetrahedron, , vol. 70, # 2 p. 434 - 438
  • Route2

    References

    • Tetrahedron, , vol. 70, # 2 p. 434 - 438
  • Route3
    • null|null
      119352-88-4
    • ~97%
    • In-stock
      N,4-Dimethylbenzenesulfonamide|CS-W016946
      640-61-9

    References

    • Laronze, Jean-Yves; Sapi, Janos; Levy, Jean Synthesis, 1988 , # 8 p. 619 - 621

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   46.17
  • LogP   0.90312
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   2

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