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CS-W001157 4
Total: USD 88.00

9-Fluorenylmethyl carbamate

  • CAS No. 84418-43-9

  • Cat. No. CS-W016703
  • Purity≥97%
  • MDL No.MFCD00237376

*For research and further manufacturing use only, not for direct human use.

9-Fluorenylmethyl carbamate|CS-W016703

Structure of 84418-43-9

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General Information

  • CAS No. 84418-43-9
  • Cat. No. CS-W016703
  • Purity ≥97%
  • MDL No. MFCD00237376
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₅H₁₃NO₂
  • Molecular Weight None
  • Synonym(s) Fmoc-NH2
  • SMILES O=C(N)OCC1C2=C(C3=C1C=CC=C3)C=CC=C2

Description

9-Fluorenylmethyl carbamate serves as a robust amino acid protecting group in peptide synthesis, offering high stability under diverse reaction conditions. The fluorenyl moiety facilitates efficient removal via mild base treatment, enabling clean deprotection without side reactions. This derivative integrates seamlessly into automated synthesis protocols, ensuring high yields and purity in complex peptide sequences.

Application

9-Fluorenylmethyl carbamate serves as a robust amino acid protecting group in peptide synthesis, offering high stability under basic conditions and efficient removal via mild base-catalyzed cleavage. Its fluorenyl chromophore enables convenient UV monitoring of reaction progress and purification by reverse-phase chromatography. The group exhibits excellent functional group tolerance and facilitates clean coupling reactions, making it a preferred choice for automated solid-phase synthesis and complex peptide assembly.

Synthesis

  • Route1
    • Fmoc-OH Amino acid impurity|CS-1733148
      24324-17-2
    • null|null
      917-61-3
    • ~94%
    • In-stock
      9-Fluorenylmethyl carbamate|CS-W016703
      84418-43-9

    References

    • Carpino, Louis A.; Mansour, E. M. E.; Cheng, C. H.; Williams, James R.; MacDonald, Russell; et al. Journal of Organic Chemistry, 1983 , vol. 48, # 5 p. 661 - 665
  • Route2
    • null|null
      27958-09-4
    • In-stock
      Fmoc-Osu Amino acid impurity|CS-1733136
      82911-69-1
    • ~%
    • In-stock
      9-Fluorenylmethyl carbamate|CS-W016703
      84418-43-9

    References

    • US2005/36997 A1, ;
  • Route3
    • null|null
      28920-43-6
    • ~%
    • In-stock
      9-Fluorenylmethyl carbamate|CS-W016703
      84418-43-9

    References

    • Tetrahedron Letters, , vol. 34, # 24 p. 3861 - 3862

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P260-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   52.32
  • LogP   2.8942
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   2

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