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CS-W001157 4
Total: USD 88.00

Cyclohexyldiphenylphosphine

  • CAS No. 6372-42-5

  • Cat. No. CS-W014043
  • Purity≥97%
  • MDL No.MFCD00046360

*For research and further manufacturing use only, not for direct human use.

Cyclohexyldiphenylphosphine|CS-W014043

Structure of 6372-42-5

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General Information

  • CAS No. 6372-42-5
  • Cat. No. CS-W014043
  • Purity ≥97%
  • MDL No. MFCD00046360
  • Storage 4°C, protect from light, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₈H₂₁P
  • Molecular Weight 268.34
  • Synonym(s) None
  • SMILES C1CCC(CC1)P(C1=CC=CC=C1)C1=CC=CC=C1

Description

A cell-permeable quinuclidinone analog.

Application

Cyclohexyldiphenylphosphine serves as a robust, bench-stable ligand in palladium-catalyzed cross-coupling reactions. Its bulky cyclohexyl group enhances steric bulk and electronic modulation, improving catalyst turnover and selectivity in Suzuki-Miyaura and Negishi couplings. The ligand exhibits excellent functional group tolerance and facilitates efficient reactions under mild conditions, making it well-suited for complex molecule synthesis and scale-up applications.

Synthesis

  • Route1

    References

    • Li, Yuehui; Das, Shoubhik; Zhou, Shaolin; Junge, Kathrin; Beller, Matthias Journal of the American Chemical Society, 2012 , vol. 134, # 23 p. 9727 - 9732
  • Route2
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      Cyclohexyldiphenylphosphine|CS-W014043
      6372-42-5

    References

    • Nandi, Partha; Dye, James L.; Bentley, Philip; Jackson, James E. Organic Letters, 2009 , vol. 11, # 8 p. 1688 - 1692
  • Route3
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    • In-stock
      Cyclohexyldiphenylphosphine|CS-W014043
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    References

    • Union Carbide Corporation Patent: US4668823 A1, 1987 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   0
  • LogP   4.452
  • H_Acceptors   0
  • H_Donors   0
  • Rotatable_Bonds   3

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