Methyl 5-chloro-4-hydroxy-1-methyl-2-oxo-1,2-dihydroquinoline-3-carboxylate

Name: Methyl 5-chloro-4-hydroxy-1-methyl-2-oxo-1,2-dihydroquinoline-3-carboxylate
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 637027-41-9
Cat. No. CS-M1951
Molecule weight267.67
Purity≥98%
MDL No.MFCD09032505

HazMat Fee +

HazMat Fee

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

The shipment is processed through FedEx Ground under the Limited Quantity option.

Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

Methyl 5-chloro-4-hydroxy-1-methyl-2-oxo-1,2-dihydroquinoline-3-carboxylate|CS-M1951

Structure of 637027-41-9

Size

Price

Quantity

* Please select Quantity before adding items.

General Information

CAS No. 637027-41-9
Cat. No. CS-M1951
Purity ≥98%
MDL No. MFCD09032505
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₂H₁₀ClNO₄
Molecular Weight 267.67
Synonym(s) 3-Quinolinecarboxylic acid, 5-chloro-1,2-dihydro-4-hydroxy-1-Methyl-2-oxo-, Methyl ester
SMILES ClC1=C2C(N(C)C(C(C(OC)=O)=C2O)=O)=CC=C1

Description

Methyl 5-chloro-4-hydroxy-1-methyl-2-oxo-1,2-dihydroquinoline-3-carboxylate features a sterically hindered quinoline core with orthogonal functional groups enabling selective derivatization. The electron-deficient ring system pairs with a bench-stable hydroxyl and ester handle, facilitating integration into bioactive scaffolds under standard conditions.

Application

Methyl 5-chloro-4-hydroxy-1-methyl-2-oxo-1,2-dihydroquinoline-3-carboxylate serves as a versatile building block for quinoline-based heterocycles, enabling efficient access to medicinally relevant scaffolds. Its hydroxyl and ester functionalities permit selective derivatization, while the chlorine substituent facilitates subsequent cross-coupling reactions. The compound exhibits bench stability and compatibility with standard purification methods, making it well-suited for iterative synthesis in medicinal chemistry and process development workflows.

Synthesis

Route1
- In-stock
  
  4743-17-3
- In-stock
  
  108-59-8
- 74-88-4
- ~67%
- In-stock
  
  637027-41-9
References
- ACTIVE BIOTECH AB Patent: US2004/34227 A1, 2004 ; Location in patent: Page 3 ;
Route2
- In-stock
  
  40707-01-5
- In-stock
  
  108-59-8
- ~93%
- In-stock
  
  637027-41-9
References
- Wennerberg, Johan; Bjoerk, Anders; Fristedt, Tomas; Granquis, Bo; Jansson, Karl; Thuvesson, Ingela Organic Process Research and Development, 2007 , vol. 11, # 4 p. 674 - 680
Route3
- In-stock
  
  20829-96-3
- In-stock
  
  6065-54-9
- 74-88-4
- ~72%
- In-stock
  
  637027-41-9
References
- ACTIVE BIOTECH AB Patent: WO2003/106424 A1, 2003 ; Location in patent: Page 5 ;

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

TPSA 68.53
LogP 1.6841
H_Acceptors 5
H_Donors 1
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Functional Group Ester

Building Blocks Skeleton Aromatic heterocycle compounds quinoline compounds

Key Words

637027-41-9 sigma637027-41-9 manufacturer637027-41-9 price637027-41-9 structure637027-41-9 SDSbuy 637027-41-9637027-41-9 supplier637027-41-9 uses637027-41-9 molecular weightprice of 637027-41-9637027-41-9 chemical name formula of 637027-41-9

Salutation:	*Country or Region:
*Applicant Name:	*Organization Name:
*Email Address:	Quantity:
CAS NO. :	Product Name:
Remarks:
Upload Pictures

CAS.No.		Product Name
Applicant Name *		Email Address *
Phone Number *		Organization Name*
Country or Region*		Quantity*
Remarks:

Product Name:
Cat. No.: .		CAS NO. :
Quantity:

Methyl 5-chloro-4-hydroxy-1-methyl-2-oxo-1,2-dihydroquinoline-3-carboxylate

CAS No. 637027-41-9

Recommended Products

General Information

Description

Application

Synthesis

References

References

References

Safety Information

Quality Control

Computational Chemistry Data

Similar Products

Other Classifications

Recently Viewed Products

Key Words